"Hello, Can We Have Your Liver?": Understanding a High-PUFA Diet.

tl;dr: A diet high in omega-6 and omega-3 polyunsaturated fatty acids has some positive effects on the body: lower weight gain, better preservation of lean mass, improved blood lipids, and increased brown adipose tissue; but also results in increased oxidative stress, mitochondrial dysfunction, and beginning of progressive liver failure.

This paper's a classic

"Fat Quality Influences the Obesogenic Effect of High Fat Diets [HFD]"

Sounds benign enough, right?  We all like quality fats...

"To investigate whether polyunsaturated fats could attenuate the above deleterious effects of high fat diets, energy balance and body composition were assessed after two weeks in rats fed isocaloric amounts of a high-fat diet (58.2% by energy) rich either in lard or safflower/linseed oil. Hepatic functionality, plasma parameters, and oxidative status were also measured. The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile...."

That's terrific!  So we just need to eat more omega-6 and omega-3 fats, and we'll be thinner with better blood cholesterol!

Post has been moved to Substack.