Monday, January 20, 2020

Mark Sisson Wants Me On Joe Rogan's Podcast

I was running in the woods on Sunday, and I got an email.

From an old colleague, who congratulated me on what Mark Sisson had said.

"Umm, what?"

Sunday with Sisson
Sisson's weekly "Sunday with Sisson" newsletter had gone out. I can't find an archive on his site, but here's a newsletter archive site (don't click on links there, they won't work correctly):
I've got an action item for you all.
If you happen to use Twitter, hop on and retweet my tweet asking Joe Rogan to have Tucker Goodrich on the podcast (or send him one of your own). Tucker has been banging the seed oil drum for many years now, and if we could get one of the strongest anti-seed oil voices onto the most popular and influential podcast in the world, the collective health of the podcast-listening community would skyrocket. Seed oils are one of those health topics that requires some time and detail. Sugar's easy to explain. Grains are too. You can hit those in a single elevator ride and get the point across. But seed oil? To really understand the predicament requires at least a 5- to 10-minute conversation.
Joe's podcasts last up to 3 or 4 hours. They are extremely long form. You can really get into the weeds, and the weeds is sometimes where you need to go.
Here's the tweet:
WOW. Thanks, Mark!

The Joe Rogan Experience is the biggest podcast in the world.

This would be an amazing honor, and a fantastic way to get what I think is the most important health message out to the world. He's had lots of great diet topics and debates, including Stephan Guyenet, Chris Kresser, Gary Taubes, and of course Mark Sisson:

Wednesday, January 8, 2020

How Mitochondrial Defects Can Cause Various Seemingly Unrelated Diseases

"A Mitochondrial Etiology of Common Complex Diseases" [1]

An hour-long discussion of how mitochondrial dysfunction can result in various chronic diseases, and how the assumption that an anatomical division of disease is a driving assumption for how medicine is organized, and how that may block correct description and diagnosis of disease.

The speaker is Douglas C. Wallace, Ph.D.; Director, Center for Mitochondrial and Epigenomic Medicine (CMEM); Professor, Department of Pathology & Laboratory Medicine, The Children's Hospital of Philadelphia.

He does an especially good job of describing how malfunction in a single organelle can cause various diseases in various seemingly unrelated organs.

Some useful quotes below the video:


"Our hypothesis (that we've been testing for the last 45 years) is that bioenergetic dysfunction lies at the nexus of the genetic and environmental "causes"; and that the "common-complex" diseases are bioenergetic diseases, and not anatomical diseases." 7:07.
"Now each cell has hundreds of thousands of these mitochondrial DNAs, and they're constantly replicating inside your cells right now. And if you doubt that they're active and vital in there, talking to each other; tonight when it's very very quiet and your spouse is not snoring if you just concentrate you'll feel them wiggling in there." 16:49 
Discussing cells with different mitochondrial genotypes from mutation and division:
"Some with good mitochondrial DNAs and high energy, some with bad mitochondrial DNAs and low energy, and if it's below the minimum energy for that tissue, then you will get a phenotype. The equivalent of a biological, a metropolitan brownout. So if there was a line voltage decline in LA, all the electrical systems wouldn't fail at one time. The first thing that would go would be the fluorescent light bulbs, then certain elevators, then certain electrical motors, but the incandescent light bulbs would just get dimmer and dimmer.  
"Well the same is true for your body. Different parts of your body rely on energy to different extents, so as the energy declines, you're going to get organ-specific symptoms of a systemic defect." 17:35 
Noting the wild variation in expression between mitochondrial defects:
"If you inherit that from your mother you're fine until midlife, and then you'll lose your hearing (sensory-neural hearing loss). But if you get treated by aminoglycoside antibiotics, you'll go deaf within a week. OK? Mutation in the tRNA leucine gene, another protein synthesis mutation at 3243; at 30 % mutant will give you diabetes, 50% mutant give your neuromuscular disease, 100% mutant and you are dead." 18:55 
He goes on with many more examples.
"So we have a quantitative genetics with totally different clinical phenotypes." 20:15 
Tissue-specific Symptomatology
"So why would there be tissue-specific symptomatology? Well because different tissues rely on mitochondrial energy for different extents [sic]... [Examples] ...So in fact when you think energetically, much of anatomy is about energetics, not anatomy." 21:12
"The take-home lesson"
"If the, in fact, the cells are sick, they cannot undergo apoptosis, then the mitochondria are released into the bloodstream, and they are perfectly good bacteria, and you're going to get inflammation. And that's why we believe all of these diseases have an inflammatory component." 23:54

He doesn't discuss my favorite topic, the impact of omega-6 fats on mitochondria and therefore health, but it fits nicely with his hypothesis. For instance, the part of mitochondria that causes the immune reaction and inflammation he describes is cardiolipin released with oxidized linoleic acid into the blood stream. [2]

Do watch the whole thing!



1. A Mitochondrial Etiology of Common Complex Diseases. UCLA CTSI; 2017. https://www.youtube.com/watch?v=1aCHrHwm_AI. Accessed December 20, 2019.

2. Tuominen Anu, Miller Yury I., Hansen Lotte F., Kesäniemi Y. Antero, Witztum Joseph L., Hörkkö Sohvi. A Natural Antibody to Oxidized Cardiolipin Binds to Oxidized Low-Density Lipoprotein, Apoptotic Cells, and Atherosclerotic Lesions. Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26(9):2096-2102. doi:10.1161/01.ATV.0000233333.07991.4a

Sunday, October 20, 2019

The Paleo Canteen Podcast: Tucker Goodrich — Goodbye Mr. Wholewheat

A new podcast interview, with Ally Houston.

This is the first of two episodes, the next one with Ken Strain and me should drop next week.

 Resources for topics discussed are below. (Yes, the format kind of stinks, but that's what happens when you do html formatting in Microsoft Excel via formulas.)

Timestamp format is Hour:Minutes:Seconds

If you find anything egregious as far as typos go, let me know in the comments.

Enjoy!

P.S. Timestamps adjusted: -26 seconds. It will match the podcast now.

0:02:13, comment: "Mr. Whole Wheat", resource: ""Diverticulitis": My Story"

0:07:53, comment: "Somewhat bizzare blogger", resource: "Malocclusion: Disease of Civilization, Part III"

0:08:20, comment: "Weston Price's book", resource: "Nutrition and Physical Degeneration"

0:12:58, comment: "Carbohydrate cravings", resource: "Linoleic Acid, Fat Rats In Labs, and Fat Humans"

0:15:21, comment: "I can't remember the term for not being able to recognize faces", resource: "Prosopagnosia Information Page"

0:15:35, comment: "Later in the attack… Supergirl", resource: "Supergirl (TV series)"

0:21:03, comment: "There's a quote that doctors always use…", resource: "The Plural of Anecdote is Data"

0:22:11, comment: "An RCT of parachutes", resource: "Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial"

0:22:28, comment: "Parachute invented by a scientist", resource: "Louis-Sebastien Lenormand"

0:25:01, comment: "The effect it had on my health", resource: "My Vitamin D Experiment"

0:25:56, comment: "ADHD… Dr. Alessio Fasano", resource: "Neurologic and Psychiatric Manifestations of Celiac Disease and Gluten Sensitivity"

0:31:28, comment: "[Dr.] Tro Kalajian", resource: "Dr. Tro's Medical Weight Loss & Direct Primary Care"

0:36:07, comment: "Dr. [Michael] Eades", resource: "The Blog of Michael R. Eades, M.D."

0:39:45, comment: "Dr. Atkin's Book", resource: "Robert C. Atkins, 72, Creator of Controversial Diet, Dies"

0:49:47, comment: "Lots of babies", resource: "RESULTS OF THE SELF-SELECTION OF DIETS BY YOUNG CHILDREN"

0:53:49, comment: "Inject either THC or 2-AG", resource: "Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2‐arachidonoyl glycerol"

0:53:50, comment: "Inject either THC or 2-AG", resource: "Observational analysis of feeding induced by Δ9-THC and anandamide"

0:53:58, comment: "2-AG goes up normally in the body", resource: "The role of fatty acids and their endocannabinoid-like derivatives in the molecular regulation of appetite"

0:54:24, comment: "They preferentially eat sugar", resource: "Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after Δ9-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716"

0:54:38, comment: "When it hits the stomach, it's triggered by seed oils", resource: "The role of fatty acids and their endocannabinoid-like derivatives in the molecular regulation of appetite"

0:55:06, comment: "There was a human drug… that blocked 2-AG's effect", resource: "Leptin-regulated endocannabinoids are involved in maintaining food intake"

0:57:00, comment: "The increase in seed oils", resource: "Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century"

0:57:22, comment: "How much is actually in people's fat tissues", resource: "Increase in Adipose Tissue Linoleic Acid of US Adults in the Last Half Century"

0:57:56, comment: "There's a couple of studies where they take people on a high carb diet", resource: "Effect of a 6-Month Intervention with Cooking Oils Containing a High Concentration of Monounsaturated Fatty Acids (Olive and Canola Oils) Compared with Control Oil in Male Asian Indians with Nonalcoholic Fatty Liver Disease"

0:57:56, comment: "There's a couple of studies where they take people on a high carb diet", resource: "Metabolites of arachidonic acid and linoleic acid in early stages of non-alcoholic fatty liver disease—A pilot study"

0:58:33, comment: "They're the leanest industrail population on Earth", resource: "Big Government, Small Bellies: What Japan Can Teach Us About Fighting Fat"

0:59:08, comment: "How sticky the starch is", resource: "Yes Virginia, The Paleo Diet Was Low-Carb"

0:59:42, comment: "The rate of periodontal disease", resource: "Periodontal Disease"

1:01:27, comment: "All of the animal populations", resource: "Lab animals and pets face obesity epidemic"

1:01:34, comment: "Racoons in Toronto are getting obese", resource: "Enhanced access to anthropogenic food waste is related to hyperglycemia in raccoons (Procyon lotor)"

1:02:03, comment: "Well you know it's pollution", resource: "HOW TINY NAURU BECAME WORLD'S FATTEST NATION"

1:05:16, comment: "French eat more calories", resource: "List of countries by food energy intake"

1:06:04, comment: "Breed's prone to obesity", resource: "A Brief Guide to the Norwegian Elkhound"

1:09:44, comment: "Diabetics are prone to infections", resource: "Infections in Diabetes Mellitus and Hyperglycemia"

1:11:32, comment: "I read Thomas Malthus' book", resource: "An Essay on the Principle of Population"

1:13:18, comment: "Our back molars grew bigger", resource: "The Story of the Human Body, pg 56 kindle edition"

1:13:22, comment: "Chimpanzees can use tools to dig up tubers", resource: "Savanna chimpanzees use tools to harvest the underground storage organs of plants"

1:13:51, comment: "A lot of the big megafauna went extinct", resource: "Global late Quaternary megafauna extinctions linked to humans, not climate change"

1:13:56, comment: "There start appearing shell middens", resource: "Shell middens as archives of past environments, human dispersal and specialized resource management"

1:14:40, comment: "We ran out of butter and animal fats", resource: "Response to Gary Taubes on Omega-6 Fats (Seed Oils) and Obesity"

1:15:33, comment: "The horrible things that corn and soybean agrictulture is doing", resource: "Perspectives On The Vulnerability Of U.S. Agriculture To Soil Erosion: Discussion"

1:16:20, comment: "I have... a couple of fantastic books about the Indians", resource: "Review: "Empire of the Summer Moon""

1:16:20, comment: "I have... a couple of fantastic books about the Indians", resource: "Plenty-coups: Chief of the Crows"

1:16:28, comment: "What did we feed 'em?", resource: "Response to Gary Taubes on Omega-6 Fats (Seed Oils) and Obesity"

1:17:34, comment: "They are all malnourished", resource: "The world health report, Chapter 4: Childhood and maternal undernutrition"

1:18:08, comment: "You retweeted an article recently by an Indian writer", resource: ""Vegetarianism in India neither comes from a love for animals or humans. It only comes from a love of power and hierarchy.""

1:28:40, comment: "The Maffetone Method", resource: "Dr. Phil Maffetone's "Big Book of Endurance Training and Racing" Review"

1:29:45, comment: "The Seven Phases of Heart-Rate Training", resource: "The Seven Phases of Heart-Rate Training"

Monday, April 1, 2019

Follow-up to 'Low-Carb Athletes: Chris Froome, Tour de France Winner 2013, '15, '16.'

Interesting details. He's not keto, or strictly low-carb, but uses it much as Zach Bitter does, tactically.

"Chris Froome has embraced many nutritional strategies during his cycling career, from consuming more Omega-3-rich salmon to repair his muscles, to stoically devouring 400g of energy-boosting rice for breakfast on race days. But one of his most potent weapons is carbohydrate-restricted training – also known as low-carb training, or simply ‘training low.’ 
"“Low-carb training teaches the body to become more efficient at burning fat as a fuel source, as opposed to just using the readily available glycogen (stored energy) in the muscles,” explains Froome... “There are two benefits. One is obviously weight-loss, as it is important to keep lean for the mountains. But the main side is the adaptation in the body to use fat as a fuel source and not depend entirely on glycogen.”... 
"Recreational athletes who copy Froome’s methods can expect to burn more fat and enjoy better stamina. “One of the main adaptations that comes with having more mitochondria in your muscles is that you use more fat for a given (exercise) intensity,” explains Morton. “That is good for endurance because fat is a good fuel source, but it also means when you need to go quicker later on, you should have more carbohydrates left. All of these adaptations happen with standard endurance training anyway, but with carbohydrate-restricted training you get more bang for your buck.”"

Thursday, March 28, 2019

Is The Dreadmill As Effective As Running Outdoors?

"Others, equally adamant, claim that treadmill miles are actually harder, perhaps because they’re stabbing themselves in the face with a fork to relieve the boredom."

Interesting. I hate the dreadmill, but it does work.