Wednesday, October 17, 2018

Linoleic Acid and Asthma: Therapies

They never actually mention linoleic acid, but they do discuss lipid peroxidation and some of the products thereof, such as malondialdehyde, which are produced from LA.

"While the specific mechanisms underlying asthma have yet to be identified, there is accumulating evidence that oxidative stress from altered GSH/GSSG redox status may play an important role in the modulation and severity of the disorder."

So the molecular mechanism section is quite incomplete.

As such, it's an annoying article, as it is a  missed opportunity from a mechanistic perspective, many of which have been described under other contexts. It also does not discuss the similarities to atherosclerosis, which are pretty obvious when reading this paper.

But the therapeutic approaches are sound, and validate the underlying concept of omega-6 fat involvement in asthma.

"Glutathione Redox Control of Asthma: From Molecular Mechanisms to Therapeutic Opportunities"

Hat tip to Chris Masterjohn.

New from Japan: What They Don’t Tell You About Culture Shock

From Grace Under Pressure

"What They Don’t Tell You About Culture Shock"

Read the whole thing!

Thursday, October 11, 2018

"Fitness versus adiposity in cardiovascular disease risk"

"Having a low VO2max increased CVD mortality risk as much or more than traditional risk factors such as diabetes mellitus, high cholesterol levels, hyperension, or current cigarette smoking"

Wow.

New from Japan: Life Updates: I’m Back! (Hopefully)

From Grace Under Pressure

"Life Updates: I’m Back! (Hopefully)"

Read the whole thing!

Friday, October 5, 2018

"Muscle damage and inflammation biomarkers after two ultra-endurance mountain races..."

About what you'd expect: exercise is hard on the body.

Due to short follow-up, it doesn't look at how quickly these indicators return to normal, as other studies have.

Wednesday, September 19, 2018

"A Grand Unified Theory of Polyunsaturated Fatty Acid Misbehaviour in Inflammatory Disease"

LOL: "But another clue was supplied by Tucker Goodrich, the PUFA ninja..."

Very interesting piece, read the whole thing.

Link via The High-fat Hep C Diet