Thursday, December 7, 2023

Fisking: "Healthy Foods High in Omega-6"

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Fisking: "Healthy Foods High in Omega-6"

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from Tucker Goodrich: yelling Stop Fisking: "Healthy Foods High in Omega-6"
This is an automated entry, comment at Substack!

Thursday, November 30, 2023

Tuesday, November 28, 2023

Quick Study Analysis: Do Seed Oils Make You Stupid?

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Quick Study Analysis: Do Seed Oils Make You Stupid?

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from Tucker Goodrich: yelling Stop Quick Study Analysis: Do Seed Oils Make You Stupid?
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Thursday, November 23, 2023

Comments

 As I'm moving off Blogger/Blogspot, I'm lowering the threshold for comments. Most of them are spam anyway. It's now set to you must be a "Member of this blog".

I have no idea how to become a member of this blog, or even if I am one. LOL.

Please follow me at Substack: tuckergoodrich.substack.com

Comments are allowed an encouraged there!

Monday, November 20, 2023

Does Linoleic Acid Induce Obesity? Part 1

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Does Linoleic Acid Induce Obesity? Part 1

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from Tucker Goodrich: yelling Stop Does Linoleic Acid Induce Obesity? Part 1
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Thursday, November 16, 2023

Tuesday, November 14, 2023

Susan Allport Eats Linoleic Acid For A Month

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Susan Allport Eats Linoleic Acid For A Month

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from Tucker Goodrich: yelling Stop Susan Allport Eats Linoleic Acid For A Month
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Tuesday, November 7, 2023

How to Cure Ménière's Disease

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How to Cure Ménière's Disease

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from Tucker Goodrich: yelling Stop How to Cure Ménière's Disease
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Sunday, October 29, 2023

Toxic blood

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Albumin from a high-linoleic acid diet (my favorite, D12492) contributes to diabetes and beta-cell failure.

"Young and Undamaged Recombinant Albumin Alleviates T2DM by Improving Hepatic Glycolysis Through Egfr and Protecting Islet Β Cells in Mice"

from Tucker Goodrich: Debugging Life Toxic blood

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Monday, October 16, 2023

Podcast Ep 9: Dave Feldman, Citizen Scientist—What Causes Heart Disease

 


Trying something new, thanks to the many issues with Blogger, and Google, in general.

New posts are going to be at the Substack I have set up, I'll make a more complete notice once I figure it out a bit better.

First one is the shownotes for this podcast, and links to the files.

Ep 9: Dave Feldman, Citizen Scientist—What Causes Heart Disease

Thursday, July 6, 2023

"Regulation of ferroptosis by lipid metabolism"

Ferroptosis = seed oil toxicity. "Sensitivity to ferroptosis is governed by the levels of peroxidizable polyunsaturated lipids..."

Link via scott dixon[Author]

Tuesday, June 20, 2023

"Enhancement of the liver's neuroprotective role ameliorates traumatic brain injury pathology"

That's a surprise! The liver dynamically produces brain-protective factors in response to injury.

Link via Hammock BD

Podcast Ep. 7 Drs. Tro Kalayjian, Brian Lenzkes, Joshua Durham—How to Save Medicine, One Practice at a Time—with Dr. Brian Kerley

Well, it's been a while.


By coincidence, episode 7 again features my physician, Dr. Joshua Durham, but this time we are honored to include Drs Tro Kalayjian and Brian Lenzkes. These two physicians have both successfully incorporated dietary therapy into their practices to help their patients overcome metabolic dysfunction.

Josh is in the beginning of this process, and that was the impetus for this discussion: how to do it.

We all figured a conversation like this would be of interest to other physicians, but I also wanted to make sure we discussed what this meant to patients.

I learned a lot, Josh learned a lot, and some of it was frankly quite surprising to me. Tro and Brian are doing great work.

Hopefully this goes a way towards rectifying this oversight from a few years back: 

Youtube:

Rumble:

Podcast:

Twitter video:


Show Notes:

Medicine needs to be fixed:

“The New Crisis of Increasing All-Cause Mortality in US Children and Adolescents”

 

Dr. Tro Kalayjian

Dr. Tro’s Medical Weight Loss

·         https://doctortro.com/

Research:

Twitter:

Dr. Brian Lenzkes

Metabolic Health:

·         San Diego: https://sandiegometabolichealth.com/

Twitter:

Dr. Joshua Durham

Twitter:

Dr. Eric Westman

·         https://ericwestmanmd.com/

New Atkins for a New You: The Ultimate Diet for Shedding Weight and Feeling Great by Eric C. Westman, Stephen D. Phinney, Jeff S. Volek

·         https://amzn.to/3qd9fzy (this link benefits the podcast!)

Philip Ovadia

Alessio Fassano

Research:

Whole30

·         https://whole30.com/

Virta

·         https://www.virtahealth.com/

Dr. Tro app

Lenzkes & Kalayjian’s podcast: Low-Carb MD Podcast

·         https://www.lowcarbmd.com/

 

_______________________________________

Co-host Dr. Brian Kerley

https://www.seedoilrebellion.com/

https://twitter.com/SeedOilDsrspctr

 

Looking to fix your diet by getting rid of seed oils?

Check out the Seedy app!

https://www.seedyapp.com/

 

Tucker Goodrich

Blog: http://yelling-stop.blogspot.com/

Youtube:   https://www.youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg

Podcast: https://sites.libsyn.com/408758

Twitter: https://twitter.com/TuckerGoodrich

_______________________________________

Friday, June 16, 2023

Interview: "How Seed Oils Oxidise Cardiolipin and Damage Your Mitochondria" with Max Gulane MD on the Regenerative Health Podcast

Max is an emergency room physician who has an interest in what underlies our chronic disease pandemic.

We spoke once before (below) and Max had some follow-up questions, which led to this interesting discussion.

In going through it to to put together the show notes, I found myself thinking that I sounded like Ray Peat, with a dense, frankly difficult-to-follow narrative style.

Yes, it's all backed by solid evidence, but it can be tough to follow, and as I commented to Max after it was finished, getting all the references was going to be a chore. It was, and I didn't attempt to track them all down.

So if you have questions, post them below.

RHP #30: "How seed oils oxidise cardiolipin and damage your mitochondriaHow seed oils oxidise cardiolipin and damage your mitochondria"

"Tucker Goodrich and I explore sub-cellular mechanisms by which seed oils are damaging your health. We cover mitochondrial bio-energetic aetiology of disease, linoleic acid and oxidation of mitochondrial cardiolipin, how seed oils contribute to visceral fat, Tucker’s opinion on Dr Jack Kruse’s work and much, much more. 
 
"This is quite a technical discussion with emphasis on the exact mechanisms of see oil harm. If you’re just learning about how seed oils damage health, I suggest listening to my first podcast with Tucker (RHP #12) for an introduction.
 
"Tucker is a financial risk analyst, self-taught engineer and citizen scientist who is a world expert in the the biochemistry of seed oils and their impact on human health.

RHP #12: "Toxic harm of seed oils, linoleic acid and lipid peroxidation products"

"Tucker Goodrich joins me to discuss seed oils, linoleic acid, 4-HNE, toxic breakdown products of linoleic acid, the evidence implicating seed oils in liver disease, obesity, diabetes, cancer and heart disease and much, much more.

He has a timeline of our discussion at the link above. Scroll down this page for the show notes.



Show notes on RHP #30

Doug Wallace on Mitochondria (T. Goodrich, 2020a)

Book by doctor with multiple sclerosis (Wahls, 2010)

Famous biologist: " ...The great tragedy of Science—the slaying of a beautiful hypothesis by an ugly fact..."—Thomas Henry Huxley

Mitochondrial ATP synthase image is here (T. Goodrich, 2016a)

Seyfried interview (T. D. Goodrich, 2021)

Danny Lauria on ‘floxxing’ (Gulhane, 2023)

Light emission from auto-oxidizing fats (Miyamoto et al., 2012)

Twin astronauts (Garrett-Bakelman et al., 2019)

Linseed oil is not a solvent. Whoops. Here’s a video on auto-oxidation: https://www.youtube.com/watch?v=9yq6VW-c2Ts

Washing machine warning label: https://twitter.com/TuckerGoodrich/status/1567573638458789890?s=20

Oxidized cardiolipin inducing apoptosis: (Kagan et al., 2005)

“How to Prevent Oxidative Damage In Your Mitochondria” (T. Goodrich, 2016b)

Anti-phospholipid syndrome and oxidized cardiolipin (Tuominen et al., 2006)

Cardiolipin composition (some of the links) (T. Goodrich, 2016a)

Linoleic acid and migraine (Ramsden et al., 2012, 2013, 2018)

HNE and pyruvate dehydrogenase (Humphries & Szweda, 1998; Vadvalkar et al., 2017)

ARDS and Leukotoxin (T. Goodrich, 2020b)

Bruce Hammock interview (Gornoski, 2021)

Bruce Hammock and Leukotoxin in COVID (McReynolds et al., 2021)

Linoleic acid is not an essential fat (Carlson et al., 2019; Le et al., 2012)

Omega-6 metabolite toxicity vs Omega-3 (Stanley et al., 2012)

Died at 102, not 103: Large radiation dose with no ill effects (Taylor et al., 2004)

Radiation and linoleic acid (Horgan et al., 1957)

Avoid animals fed high amounts of seed oils (Midtbø et al., 2013)

Lard is obesogenic when coming from industrially-fed pigs (T. Goodrich, 2011)

Linoleic acid preferentially burned from adipose tissue when fasted (Cunnane et al., 2001)

 

References

 

Carlson, S. J., O’Loughlin, A. A., Anez-Bustillos, L., Baker, M. A., Andrews, N. A., Gunner, G., Dao, D. T., Pan, A., Nandivada, P., Chang, M., Cowan, E., Mitchell, P. D., Gura, K. M., Fagiolini, M., & Puder, M. (2019). A Diet With Docosahexaenoic and Arachidonic Acids as the Sole Source of Polyunsaturated Fatty Acids Is Sufficient to Support Visual, Cognitive, Motor, and Social Development in Mice. Frontiers in Neuroscience, 13, 72. https://doi.org/10.3389/fnins.2019.00072

Cunnane, S. C., Ross, R., Bannister, J. L., & Jenkins, D. J. (2001). Beta-oxidation of linoleate in obese men undergoing weight loss. The American Journal of Clinical Nutrition, 73(4), 709–714. https://doi.org/10.1093/ajcn/73.4.709

Garrett-Bakelman, F. E., Darshi, M., Green, S. J., Gur, R. C., Lin, L., Macias, B. R., McKenna, M. J., Meydan, C., Mishra, T., Nasrini, J., Piening, B. D., Rizzardi, L. F., Sharma, K., Siamwala, J. H., Taylor, L., Vitaterna, M. H., Afkarian, M., Afshinnekoo, E., Ahadi, S., … Turek, F. W. (2019). The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science, 364(6436), eaau8650. https://doi.org/10.1126/science.aau8650

Goodrich, T. (2011, November 19). Linoleic Acid, Fat Rats in Labs, and Fat Humans. Yelling Stop. http://yelling-stop.blogspot.com/2011/11/linoleic-acid-fat-rats-in-labs-and-fat.html

Goodrich, T. (2016a, February 5). The Cause of Metabolic Syndrome: Excess Omega-6 Fats (Linoleic Acid) in Your Mitochondria. Yelling Stop. http://yelling-stop.blogspot.com/2016/02/the-cause-of-metabolic-syndrome-excess.html

Goodrich, T. (2016b, February 23). How To Prevent Oxidative Damage In Your Mitochondria. Yelling Stop. http://yelling-stop.blogspot.com/2016/02/how-to-prevent-oxidative-damage-in-your.html

Goodrich, T. (2020a, January 8). How Mitochondrial Defects Can Cause Various Seemingly Unrelated Diseases. Yelling Stop. https://yelling-stop.blogspot.com/2020/01/how-mitochondrial-defects-can-cause.html

Goodrich, T. (2020b, June 2). Does Consumption of Omega-6 Seed Oils Worsen ARDS and COVID-19? [Blog]. Yelling Stop. http://yelling-stop.blogspot.com/2020/06/does-consumption-of-omega-6-seed-oils.html

Goodrich, T. D. (2021, July 8). Interview: Thomas Seyfried on Glioblastoma, Metabolic Cancer Breakthroughs, with David Gornoski on A Neighbor’s Choice [Blog]. Yelling Stop. https://yelling-stop.blogspot.com/2021/07/podcast-interview-thomas-seyfried-with.html

Gornoski, D. (2021, May 24). Omega 6 Linoleic Acid Research with Prof. Bruce Hammock, Prof. Bruce German, and Tucker Goodrich (No. 5/24/2021) [Mp3]. https://aneighborschoice.com/omega-6-linoleic-acid-research-with-prof-bruce-hammock-prof-bruce-german-and-tucker-goodrich/

Gulhane, M. (2023, May 23). Danny Lauria: Recovering from “floxxing” with mitochondrial and circadian practices (No. 25) [Mp3]. https://podcasts.apple.com/us/podcast/regenerative-health-with-max-gulhane-md/id1661751206

Horgan, V. J., Philpot, J. S. L., Porter, B. W., & Roodyn, D. B. (1957). Toxicity of autoxidized squalene and linoleic acid, and of simpler peroxides, in relation to toxicity of radiation. Biochemical Journal, 67(4), 551–558. https://doi.org/10.1042/bj0670551

Humphries, K. M., & Szweda, L. I. (1998). Selective Inactivation of α-Ketoglutarate Dehydrogenase and Pyruvate Dehydrogenase: Reaction of Lipoic Acid with 4-Hydroxy-2-nonenal. Biochemistry, 37(45), 15835–15841. https://doi.org/10.1021/bi981512h

Kagan, V. E., Tyurin, V. A., Jiang, J., Tyurina, Y. Y., Ritov, V. B., Amoscato, A. A., Osipov, A. N., Belikova, N. A., Kapralov, A. A., Kini, V., Vlasova, I. I., Zhao, Q., Zou, M., Di, P., Svistunenko, D. A., Kurnikov, I. V., & Borisenko, G. G. (2005). Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors. Nature Chemical Biology, 1(4), Article 4. https://doi.org/10.1038/nchembio727

Le, H. D., Meisel, J. A., de Meijer, V. E., Fallon, E. M., Gura, K. M., Nose, V., Bistrian, B. R., & Puder, M. (2012). Docosahexaenoic Acid and Arachidonic Acid Prevent Essential Fatty Acid Deficiency and Hepatic Steatosis. Journal of Parenteral and Enteral Nutrition, 36(4), 431–441. https://doi.org/10.1177/0148607111414580

McReynolds, C. B., Cortes-Puch, I., Ravindran, R., Khan, I. H., Hammock, B. G., Shih, P. B., Hammock, B. D., & Yang, J. (2021). Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections. Frontiers in Physiology, 12. https://doi.org/10.3389/fphys.2021.663869

Midtbø, L. K., Ibrahim, M. M., Myrmel, L. S., Aune, U. L., Alvheim, A. R., Liland, N. S., Torstensen, B. E., Rosenlund, G., Liaset, B., Brattelid, T., Kristiansen, K., & Madsen, L. (2013). Intake of farmed Atlantic salmon fed soybean oil increases insulin resistance and hepatic lipid accumulation in mice. PloS One, 8(1), e53094. https://doi.org/10.1371/journal.pone.0053094

Miyamoto, S., Nantes, I. L., Faria, P. A., Cunha, D., Ronsein, G. E., Medeiros, M. H. G., & Di Mascio, P. (2012). Cytochrome c-promoted cardiolipin oxidation generates singlet molecular oxygen. Photochemical & Photobiological Sciences, 11(10), 1536. https://doi.org/10.1039/c2pp25119a

Ramsden, C. E., Faurot, K. R., Zamora, D., Suchindran, C. M., MacIntosh, B. A., Gaylord, S., Ringel, A., Hibbeln, J. R., Feldstein, A. E., Mori, T. A., Barden, A., Lynch, C., Coble, R., Mas, E., Palsson, O., Barrow, D. A., & Mann, D. J. (2013). Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: A randomized trial. Pain, 154(11), 2441–2451. https://doi.org/10.1016/j.pain.2013.07.028

Ramsden, C. E., Hennebelle, M., Schuster, S., Keyes, G. S., Johnson, C. D., Kirpich, I. A., Dahlen, J. E., Horowitz, M. S., Zamora, D., Feldstein, A. E., McClain, C. J., Muhlhausler, B. S., Makrides, M., Gibson, R. A., & Taha, A. Y. (2018). Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in mice. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1863(10), 1206–1213. https://doi.org/10.1016/j.bbalip.2018.07.007

Ramsden, C. E., Ringel, A., Feldstein, A. E., Taha, A. Y., MacIntosh, B. A., Hibbeln, J. R., Majchrzak-Hong, S. F., Faurot, K. R., Rapoport, S. I., Cheon, Y., Chung, Y.-M., Berk, M., & Douglas Mann, J. (2012). Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. Prostaglandins, Leukotrienes and Essential Fatty Acids, 87(4), 135–141. https://doi.org/10.1016/j.plefa.2012.08.004

Stanley, W. C., Dabkowski, E. R., Ribeiro, R. F., & O’Connell, K. A. (2012). Dietary Fat and Heart Failure: Moving from Lipotoxicity to Lipoprotection. Circulation Research, 110(5), 764–776. https://doi.org/10.1161/CIRCRESAHA.111.253104

Taylor, N. W., Sinclair, W. K., & Gorson, R. O. (2004). In Memoriam: Lauriston S. Taylor [Informational]. Health Physics Society. http://hps.org/

Tuominen, A., Miller, Y. I., Hansen, L. F., Kesäniemi, Y. A., Witztum, J. L., & Hörkkö, S. (2006). A Natural Antibody to Oxidized Cardiolipin Binds to Oxidized Low-Density Lipoprotein, Apoptotic Cells, and Atherosclerotic Lesions. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(9), 2096–2102. https://doi.org/10.1161/01.ATV.0000233333.07991.4a

Vadvalkar, S. S., Matsuzaki, S., Eyster, C. A., Giorgione, J. R., Bockus, L. B., Kinter, C. S., Kinter, M., & Humphries, K. M. (2017). Decreased Mitochondrial Pyruvate Transport Activity in the Diabetic Heart Role of Mitochondrial Pyruvate Carrier 2 (mpc2) Acetylation. Journal of Biological Chemistry, 292(11), 4423–4433. https://doi.org/10.1074/jbc.M116.753509

Wahls, T. L. (2010). Minding My Mitochondria 2nd Edition: How I overcame secondary progressive multiple sclerosis (MS) and got out of my wheelchair. (2nd edition). TZ Press. https://amzn.to/3v6G03s

 

Wednesday, May 31, 2023

"Calorie restriction and pravastatin administration during pregnancy in obese rhesus macaques modulates maternal and infant metabolism and infant brain and behavioral development"

"...negative impacts were also found in both mothers and infants. Our study emphasizes the importance of assessing gestational interventions for maternal obesity on both maternal and offspring long-term outcomes."

Link via Taha AY

Tuesday, May 23, 2023

"Neuroprotective effect of herbal extracts inhibiting soluble epoxide hydrolase (sEH) and cyclooxygenase (COX) against chemotherapy-induced cognitive impairment in mice"

Interesting. (The memory-preserving compound is known commercially as "Mentat". Heh.) "Chemotherapy-induced cognitive impairment (CICI) is a novel clinical condition characterized by memory, learning, and motor function deficits. Oxidative stress and inflammation are potential factors contributing to chemotherapy's adverse effects on the brain. Inhibition of soluble epoxide hydrolase (sEH) has been proven effective in neuroinflammation and reversal of memory impairment."

Link via Hammock BD

Tuesday, February 14, 2023

"What Should I Eat?" A Call To Action: The Seedy App

One question I get continuously is about how and what to eat if you are trying to avoid seed oils.

While it seems simple at first, since vegetable oils of one type or another are in the vast majority of processed foods, this is not a simple question.

I once spent my lunch hour in the salad dressing aisle at Whole Foods, trying to figure out what to eat. I read every single label, and finally found one single dressing that listed olive oil as its sole fat ingredient—no other oil. Most 'cream' dressings are more soybean oil than dairy!

So it's certainly not as simple as question as it might seem at first.

People reducing their seed oil intake (starting with me!) have reported the following benefits:

  • Lost weight.
  • Reduced blood pressure.
  • Reduced insulin resistance.
  • Improvement of fatty liver disease.
  • Resolution of auto-immune conditions.
  • Reduced susceptibility to sunburn

Two of the people experiencing such benefits are Ashley and Dr. Brian Kerley . 

They have faced a similar conundrum, as they removed seed oils from their diets they experienced benefits to their health, but they encountered the same difficulty in finding seed-oil free foods, and as they started spreading the news, they started encountering more and more people with the same questions. (See our discussion on YouTube below.)

Ashley initially started going to supermarkets and doing what I had done, going through the aisles and reading the labels, but she was compiling lists that people could buy as PDFs. These were very popular, but not super-easy to use, and obviously don't scale well. This was part of their Seed Oil Rebellion.

Visit the Seed Oil Rebellion site.

A fellow with some experience in mobile apps reached out to Ashley and Brian with the idea of an app that folks could use while in the supermarket, and he had an alpha version fleshed out.

The initial version worked well as a proof-of-concept, and fulfilled some basic requirements, but getting it to the next step is going to require some more effort.

Why Is This Important?

  1. We think this is the biggest health issue of our times. Just speaking about America, the vast majority of Americans (some studies find ~90%) are sick with some sort of "chronic disease" such as heart disease, certain types of cancer, obesity, diabetes, or an auto-immune condition. All of these diseases are related to linoleic acid from seed oil consumption in one way or another, according to the medical research.
  2. Government-sponsored research shows clear health risks from seed oils. For instance, two of the most commonly-used oils, canola and soybean, contain alpha-linolenic acid, which converts to a carcinogen when heated, and is the only recognized cause for an increasing epidemic of lung-cancer in non-smoking women around the world. The similar omega-6 fat in all seed oils is linoleic acid, and it produces a similar chemical, which the U.S. National Toxicology Program found "could be expected" to be carcinogenic. They did this analysis in response to a request from the National Cancer Institute. It's a mystery why they didn't complete the research into potential carcinogenicity of a major food source in the U.S. These are only two of the many toxic compounds produced by cooking with and consuming seed oils.
  3. Government agenciesinfluential non-government organizations, and other medical professionals nevertheless continue to recommend the consumption of seed oils. It's clear that any change in policy may take further decades to occur. Can we wait?
  4. Consumer pressure can accomplish what governments will fail to attempt. Removal of trans-fats, for instance, began when corporations like Cargill and McDonalds recognized the hazards and responded to anticipated customer demand. This occurred long before the FDA was embarrassed into banning them. Cargill recommended a fat that would produce lower amounts of toxins, and while this was done for economic reasons, the outcome is the same: greater health benefits for consumers of McDonald's' products.
  5. Increasing our individual health can cause a fundamental reshaping of the obesogenic food environment. But as more people are able to make this change, corporations will notice and will start to respond to the demand by producing better food options, and choosing healthier, more environmentally sound fat sources such as dairy, Zero Acre's Cultured Oil, and other low-linoleic.

What Should You Do?

If you would like to support or participate in the seed oil rebellion, please visit our Seedy web site and help us* get this project to the next phase of development, while helping transform the American and world food supply to a healthier direction.

Please Visit The Seedy App Website!



* Ashley, Brian, and I are all founding stockholders in Seedy App Inc.