The most illuminating moment I had concerning running form was when I got lost on a trail run, and had to get back in the dark.
It turned out running in the dark was easier than walking, and the fact that I couldn't see what I was stepping on in my Vibram FiveFingers made it easier, not harder.
I realized my brain was just interfering with my body, like an annoying backseat driver.
One it was forced by blindness to shut up, things went much more smoothly .
They never actually mention linoleic acid, but they do discuss lipid peroxidation and some of the products thereof, such as malondialdehyde, which are produced from LA.
"While the specific mechanisms underlying asthma have yet to be identified, there is accumulating evidence that oxidative stress from altered GSH/GSSG redox status may play an important role in the modulation and severity of the disorder."
So the molecular mechanism section is quite incomplete.
As such, it's an annoying article, as it is a missed opportunity from a mechanistic perspective, many of which have been described under other contexts. It also does not discuss the similarities to atherosclerosis, which are pretty obvious when reading this paper.
But the therapeutic approaches are sound, and validate the underlying concept of omega-6 fat involvement in asthma.
"Glutathione Redox Control of Asthma: From Molecular Mechanisms to Therapeutic Opportunities"
Hat tip to Chris Masterjohn.
"Having a low VO2max increased CVD mortality risk as much or more than traditional risk factors such as diabetes mellitus, high cholesterol levels, hyperension, or current cigarette smoking"
Wow.
