"Amber, Tucker, and Raphael on Satiety, Satiation, Overeating, Food Reward, Obesity, and Palatability"

That was fun! 

"Both Amber and Tucker were on the podcast previously. 

"They're back today for a chat about satiety, satiation, overeating, food reward, obesity & palatability. 

"It all started from a disagreement on Twitter

I would love to do a podcast on the questions of satiation/satiety/food reward/obesity with the both of you @KetoCarnivore @TuckerGoodrich - should we set it up? Maybe shortly before Christmas so we have time to prepare

— Raphael Sirtoli (@raphaels7) November 21, 2021

"Follow Tucker on Twitter @tuckergoodrich https://twitter.com/TuckerGoodrich.

"Amber's website is https://www.mostly-fat.com/ and her bio https://facultativecarnivore.com/about-the-author/. She's @ketocarnivore on Twitter. Her book on the carnivore diet is coming out chapter by chapter, so keep an eye out for it."

We discussed, among other things, these two posts:

Does Linoleic Acid Induce Obesity? A Response to Stephan Guyenet, Part 1

Does Linoleic Acid Induce Obesity? A Response to Stephan Guyenet. Part 2

Peter Dobromylskyj looked into it, and found a very interesting study on the effect of CB1 KO in adipocytes:

"Rimonabant and adipocytes"

"The hypothalamic Reward™ dopaminergic neurons are left untouched. All that happens is that adipocytes lose (at least) the insulin sensitising effect of CB1 receptor activation. Weight completely normalises in less than a month. It's also worth noting that in control mice adipocyte CB1 gene deletion does nothing."

"Fascinating", indeed. 

There's a LOT going on here that we don't understand.

Short post on that to follow...

I Caught A Cold

No, not "the" cold. Two COVID-19 antigen tests were negative, the second in the thick of the symptoms.

It started as a simple head cold, which nevertheless was able to quite knock me out for a bunch of days.

Lack of sleep due to a flight from Idaho to Newark, NJ through Seattle in the thick of the recent Seattle snow apocalypse was likely the cause of it. 

Getting this message in the middle of taking off while flying to Seattle probably kicked off some stress, and the combination of that and lack of sleep is not good for one's immune system!

It's then progressed to bronchitis, and has put me quite behind on some projects I am working on.

So if you are wondering where I've been, and why I won't be around much for the next few weeks. that's the answer.

The COVID tests were done for the friends and family we were visiting. My parents-in-law are both 80, and while quite healthy, are obviously concerned about the ill effects of that particular virus on older people.