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| From (Li et al., 2021) |
It's Envigo's TD.96355, from a paper finding negative effects of a keto diet.
"Ketogenic diet aggravates colitis, impairs intestinal barrier and alters gut microbiota and metabolism in DSS-induced mice" (Li et al., 2021)
F3666 is another rodent keto diet, (Lecker, 2011). It's also high in seed oils, and it's also commonly used.
Virta Health explicitly advises patients to limit seed oil consumption (Phinney et al., 2020), based on Phinney's labratory experience and self-experimentation, in which he found seed oils to be acutely, albeit mildly, toxic:
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Hi, the study Wood referred to https://gut.bmj.com/content/58/12/1606.long
ReplyDeleteThis is not very popular? An ibm expert in my country would not touch this with a stick, i presume. However, this is unusually large risk coefficient. This had ffq, wonder if they followed up with more reliable method.
JR
Dear mr. Goodrich,
ReplyDeleteI realise that this post is not the place to post my request, convenient though, so here we go: could you please, please, please do your AHS-presentation on cancer after all? I was really sorry to hear your presentation on cancer was cancelled at the AHS because of time restrictions. This world needs smart guys like you connecting pieces of knowledge from different disciplines of science, making a integrated model or hypothesis that can be tested etc. So, could you please do your presentation? Maybe on the podcast with David G?
As biologist (with a master in paleo-ecology) and as (near) future dietitian, I am really impressed and inspired by your work, so keep at it! Kind regards from the Netherlands, Gerlach.
NB: I have listened to your work and others extensively, am I correct in summarizing the process of cancer like this: Excessive intake of LA above evolutionary correct levels of approx. 2% DEI; incorporation of excess LA in Cardiolipine; per-oxidation of Cardiolipine in the presence of iron of the cytochrome complexes; collapse of the electron transport chain; collapse of ATP-production; the absence of an apoptosis signal from the mitochondria due to DNA damage there (maybe due to the PR53 damage); due to the obstruction of apoptosis, the cell has to revert to cytoplasmatic fermentation for energy (Warburg effect); due to DNA damage of the cell and mitochondria (maybe due to the PR53 damage), the cell reverts to primordial DNA and reverts to a primordial single-cell state (as opposed to multi-cell tissue of organism); in this primordial state, this cell keeps dividing in an environment rich in glucose of glutamine? Like I said, I am really looking forward to your presentation!
It will get done, I'm working on a project that includes the cancer mechanism. Thanks for your feedback!
DeleteSorry if this is a remedial question but I’m new to this. Wouldn’t hydrogenated vegetable shortening have low or zero n-6? I thought that was the point of hydrogenation.
ReplyDeleteOn a somewhat different topic, "Palm Olein" is another oil showing up on grocery store shelves. Please let me know if this is another PUFA-laden oil that you would stay away from. Thanks for all your work against seed oils. I'm another anecdote of better living by meticulously avoiding vegetable oils.
ReplyDeleteHi, pufas and enhanced covid may be of interest
ReplyDeletehttps://www.gastrojournal.org/article/S0016-5085(20)34727-2/fulltext#back-bib7
JR