"Dietary Combination of Sucrose and Linoleic Acid Causes Skeletal Muscle Metabolic Abnormalities..."

"...in Zucker fatty rats through specific modification of fatty acid composition" 

"Diet is the most important etiological factor involved in the onset of metabolic syndrome and type-2 diabetes. ...However, to our knowledge, little is known about the relationship between the implications of nutritional interactions and the development of metabolic disorders. 

"Previously, we demonstrated that a dietary combination of sucrose and linoleic acid (SL) could contribute strongly to the development of metabolic disorders in Zucker fatty rats at 8 weeks compared with other isocaloric diets containing different combinations of carbohydrate and fat, including more ameliorative palatinose (also known as isomaltulose, a sucrose analogue) and oleic acid (C18:1 n-9).⁽¹⁾ We hypothesized that metabolic abnormalities may have already occurred before the 8 weeks. Investigation of this earlier event is necessary to understand the underlying mechanisms of metabolic abnormalities or beneficial effects caused by a combination of dietary carbohydrate and fat....

"...linoleic acid and arachidonic acid per se have been reported to have an insulinotropic effect on pancreatic beta-cells.^(27–30)... 

"...In conclusion, we demonstrate that the adverse consequences of a dietary combination of sucrose and linoleic acid in Zucker fatty rats can be initiated by abnormal lipid metabolism in the skeletal muscle. Although the underlying mechanism is still under investigation, an abnormal accumulation of cellular arachidonic acid may be involved in the molecular basis of metabolic abnormalities in the skeletal muscle. Our findings suggest that a selective combination between dietary carbohydrates and fats can induce compositional and distributional changes in intracellular fatty acids in specific tissues, resulting in the development of metabolic disorders."