Sunday, November 22, 2020

Follow-up to "Does Consumption of Omega-6 Seed Oils Worsen ARDS and COVID-19?"

Two gentlemen were kind enough to send along the full text of a study I only referenced by abstract in that original post.

I've updated the post accordingly, and for those who'd rather not dig through it, here's the update:

PS: Thanks to Drs. Toshi Clark and Joseph Mercola for sending the full text of 1.02 to me.
Here's the summary of that paper:

"...This latter finding suggests that peroxidation of linoleic acid seen in the plasma of patients with ARDS probably occurs in the lung, since the lung is undergoing oxidative stress from sequestered neutrophils, and from ventilatory support with high FIO2.  
"The data further suggest that providing lipid substrates in the form of enteral or parenteral nutrition to patients experiencing severe oxidative stress may greatly exacerbate the underlying disease process. Specific and sensitive measurements of changes in the plasma polyunsaturated fatty acid linoleic acid, and one of its oxidation products, 4-hydroxy-2-nonenal, support the proposal that patients with established ARDS are under severe oxidative stress from their disease and from treatment with high FIO2 concentrations."

Emphasis mine.  The lipid substrate used was Intralipid, discussed above.

Here's the paper: 

1.02.
Quinlan GJ, Lamb NJ, Evans TW, Gutteridge JMC. Plasma fatty acid changes and increased lipid peroxidation in patients with adult respiratory distress syndrome. Read Online: Critical Care Medicine | Society of Critical Care Medicine. 1996;24(2):241–246. doi:10.1097/00003246-199602000-00010

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