Several years ago [1.01] I came across the following paper [1.02]:
"Plasma FA changes and incr. lipid peroxidation in patients with ARDS"— Tucker Goodrich (@TuckerGoodrich) April 25, 2017
Showing LA converting to HNE. https://t.co/ht8n0Zt6ZW @puddleg
While I have only been able to access the abstract [got it, see PS at end], it's pretty telling of something I've seen implied in a number of different disease processes:
"Conclusions: During intensive care treatment, patients with ARDS decrease their percentage plasma concentrations of total plasma linoleic acid, but increase their percentage concentrations of oleic and palmitoleic acids. As plasma linoleic acid concentrations decreased, there was usually an increase in plasma 4-hydroxy-2-nonenal [HNE] values, one of its specific peroxidation products, suggestive of severe oxidative stress leading to molecular damage to lipids."HNE is a highly toxic breakdown product of omega-6 fatty acids (n-6), such as the linoleic acid mentioned above, that has been implicated in a number of different disease processes. [1.3] It's also a commonly-used marker of oxidative stress (OxStr), a process in which primarily n-6 fats in different cell structures are broken down into various toxins, including HNE. Linoleic acid is the n-6 fatty acid which is most commonly consumed in an industrial diet.
This was the first time I'd seen an example of this breakdown happening during the course of a disease, so I made note of it.
2. ARDS is the process by which SARS kills you.
The post moved to Substack.
Another great study!
ReplyDeleteSide note: Thomas DeLauer is pushing 100% Omega 6 as a good thing - at least for sesame oil.
He even recommends cooking in it.
100% Omega 6 linoleic acid for your cooking? I'm getting cognitive dissonance now.
His video on it:
https://www.youtube.com/watch?v=xAoZmapMKZY
Hi, a bit of the topic... alcohol and o-6.
ReplyDeletehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808136/
This is certainly not new to you, even though not posted by you, I seached with alcohol.
Even in here, sat is protective and pufa destructive. Very much so.
Author Kirpitch has several on this theme.
Rgds JR
First comment wiped out by preview. Second attempt. Enjoying your blog immensely, after years of reading Hyperlipid and I wasn't really aware of your stuff. Very interesting, all the LA info, especially when looking at how to reverse metabolic syndrome rather than just stall or manage it with low carb.
ReplyDelete