Sunday, January 28, 2018

Meta-analysis of Oxidative Stress and Alzheimer's

No clear effect, little research. Did not look at focal analysis of specific regions or organelles.

"The field of oxidative stress as it relates to AD is large, with primary data coming from many different systems and supplemented by a large and rapidly growing narrative review literature. While this volume of data indicates intense interest in this topic, its utility is diminished by obfuscating or masking the complete picture of the oxidative changes in the AD brain. The purpose of this analysis was to quantitatively address this problem specifically for oxidative-stress related changes in the human AD brain. The pattern of oxidative changes identified in this analysis suggests that the antioxidant enzyme system in the brain is largely intact in AD and the global accumulation of oxidative damage is less substantial than has generally been reported."

And this:

"While this [brain malondialdehyde (MDA) level] is not the most specific or robust marker of lipid peroxidation, it is the most commonly studied marker of lipid peroxidation in AD brain..."

Sigh.

An excellent, comprehensive meta-analysis, well worth reading just to admire the work.

"Markers of oxidative damage to lipids, nucleic acids and proteins and antioxidant enzymes activities in Alzheimer's disease brain: A meta-analysis in human pathological specimens"