Thursday, July 6, 2023

"Regulation of ferroptosis by lipid metabolism"

Ferroptosis = seed oil toxicity. "Sensitivity to ferroptosis is governed by the levels of peroxidizable polyunsaturated lipids..."

Link via scott dixon[Author]

Tuesday, June 20, 2023

"Enhancement of the liver's neuroprotective role ameliorates traumatic brain injury pathology"

That's a surprise! The liver dynamically produces brain-protective factors in response to injury.

Link via Hammock BD

Podcast Ep. 7 Drs. Tro Kalayjian, Brian Lenzkes, Joshua Durham—How to Save Medicine, One Practice at a Time—with Dr. Brian Kerley

Well, it's been a while.

By coincidence, episode 7 again features my physician, Dr. Joshua Durham, but this time we are honored to include Drs Tro Kalayjian and Brian Lenzkes. These two physicians have both successfully incorporated dietary therapy into their practices to help their patients overcome metabolic dysfunction.

Josh is in the beginning of this process, and that was the impetus for this discussion: how to do it.

We all figured a conversation like this would be of interest to other physicians, but I also wanted to make sure we discussed what this meant to patients.

I learned a lot, Josh learned a lot, and some of it was frankly quite surprising to me. Tro and Brian are doing great work.

Hopefully this goes a way towards rectifying this oversight from a few years back: 




Twitter video:

Show Notes:

Medicine needs to be fixed:

“The New Crisis of Increasing All-Cause Mortality in US Children and Adolescents”


Dr. Tro Kalayjian

Dr. Tro’s Medical Weight Loss




Dr. Brian Lenzkes

Metabolic Health:

·         San Diego:


Dr. Joshua Durham


Dr. Eric Westman


New Atkins for a New You: The Ultimate Diet for Shedding Weight and Feeling Great by Eric C. Westman, Stephen D. Phinney, Jeff S. Volek

· (this link benefits the podcast!)

Philip Ovadia

Alessio Fassano






Dr. Tro app

Lenzkes & Kalayjian’s podcast: Low-Carb MD Podcast




Co-host Dr. Brian Kerley


Looking to fix your diet by getting rid of seed oils?

Check out the Seedy app!


Tucker Goodrich






Friday, June 16, 2023

Interview: "How Seed Oils Oxidise Cardiolipin and Damage Your Mitochondria" with Max Gulane MD on the Regenerative Health Podcast

Max is an emergency room physician who has an interest in what underlies our chronic disease pandemic.

We spoke once before (below) and Max had some follow-up questions, which led to this interesting discussion.

In going through it to to put together the show notes, I found myself thinking that I sounded like Ray Peat, with a dense, frankly difficult-to-follow narrative style.

Yes, it's all backed by solid evidence, but it can be tough to follow, and as I commented to Max after it was finished, getting all the references was going to be a chore. It was, and I didn't attempt to track them all down.

So if you have questions, post them below.

RHP #30: "How seed oils oxidise cardiolipin and damage your mitochondriaHow seed oils oxidise cardiolipin and damage your mitochondria"

"Tucker Goodrich and I explore sub-cellular mechanisms by which seed oils are damaging your health. We cover mitochondrial bio-energetic aetiology of disease, linoleic acid and oxidation of mitochondrial cardiolipin, how seed oils contribute to visceral fat, Tucker’s opinion on Dr Jack Kruse’s work and much, much more. 
"This is quite a technical discussion with emphasis on the exact mechanisms of see oil harm. If you’re just learning about how seed oils damage health, I suggest listening to my first podcast with Tucker (RHP #12) for an introduction.
"Tucker is a financial risk analyst, self-taught engineer and citizen scientist who is a world expert in the the biochemistry of seed oils and their impact on human health.

RHP #12: "Toxic harm of seed oils, linoleic acid and lipid peroxidation products"

"Tucker Goodrich joins me to discuss seed oils, linoleic acid, 4-HNE, toxic breakdown products of linoleic acid, the evidence implicating seed oils in liver disease, obesity, diabetes, cancer and heart disease and much, much more.

He has a timeline of our discussion at the link above. Scroll down this page for the show notes.

Show notes on RHP #30

Doug Wallace on Mitochondria (T. Goodrich, 2020a)

Book by doctor with multiple sclerosis (Wahls, 2010)

Famous biologist: " ...The great tragedy of Science—the slaying of a beautiful hypothesis by an ugly fact..."—Thomas Henry Huxley

Mitochondrial ATP synthase image is here (T. Goodrich, 2016a)

Seyfried interview (T. D. Goodrich, 2021)

Danny Lauria on ‘floxxing’ (Gulhane, 2023)

Light emission from auto-oxidizing fats (Miyamoto et al., 2012)

Twin astronauts (Garrett-Bakelman et al., 2019)

Linseed oil is not a solvent. Whoops. Here’s a video on auto-oxidation:

Washing machine warning label:

Oxidized cardiolipin inducing apoptosis: (Kagan et al., 2005)

“How to Prevent Oxidative Damage In Your Mitochondria” (T. Goodrich, 2016b)

Anti-phospholipid syndrome and oxidized cardiolipin (Tuominen et al., 2006)

Cardiolipin composition (some of the links) (T. Goodrich, 2016a)

Linoleic acid and migraine (Ramsden et al., 2012, 2013, 2018)

HNE and pyruvate dehydrogenase (Humphries & Szweda, 1998; Vadvalkar et al., 2017)

ARDS and Leukotoxin (T. Goodrich, 2020b)

Bruce Hammock interview (Gornoski, 2021)

Bruce Hammock and Leukotoxin in COVID (McReynolds et al., 2021)

Linoleic acid is not an essential fat (Carlson et al., 2019; Le et al., 2012)

Omega-6 metabolite toxicity vs Omega-3 (Stanley et al., 2012)

Died at 102, not 103: Large radiation dose with no ill effects (Taylor et al., 2004)

Radiation and linoleic acid (Horgan et al., 1957)

Avoid animals fed high amounts of seed oils (Midtbø et al., 2013)

Lard is obesogenic when coming from industrially-fed pigs (T. Goodrich, 2011)

Linoleic acid preferentially burned from adipose tissue when fasted (Cunnane et al., 2001)




Carlson, S. J., O’Loughlin, A. A., Anez-Bustillos, L., Baker, M. A., Andrews, N. A., Gunner, G., Dao, D. T., Pan, A., Nandivada, P., Chang, M., Cowan, E., Mitchell, P. D., Gura, K. M., Fagiolini, M., & Puder, M. (2019). A Diet With Docosahexaenoic and Arachidonic Acids as the Sole Source of Polyunsaturated Fatty Acids Is Sufficient to Support Visual, Cognitive, Motor, and Social Development in Mice. Frontiers in Neuroscience, 13, 72.

Cunnane, S. C., Ross, R., Bannister, J. L., & Jenkins, D. J. (2001). Beta-oxidation of linoleate in obese men undergoing weight loss. The American Journal of Clinical Nutrition, 73(4), 709–714.

Garrett-Bakelman, F. E., Darshi, M., Green, S. J., Gur, R. C., Lin, L., Macias, B. R., McKenna, M. J., Meydan, C., Mishra, T., Nasrini, J., Piening, B. D., Rizzardi, L. F., Sharma, K., Siamwala, J. H., Taylor, L., Vitaterna, M. H., Afkarian, M., Afshinnekoo, E., Ahadi, S., … Turek, F. W. (2019). The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science, 364(6436), eaau8650.

Goodrich, T. (2011, November 19). Linoleic Acid, Fat Rats in Labs, and Fat Humans. Yelling Stop.

Goodrich, T. (2016a, February 5). The Cause of Metabolic Syndrome: Excess Omega-6 Fats (Linoleic Acid) in Your Mitochondria. Yelling Stop.

Goodrich, T. (2016b, February 23). How To Prevent Oxidative Damage In Your Mitochondria. Yelling Stop.

Goodrich, T. (2020a, January 8). How Mitochondrial Defects Can Cause Various Seemingly Unrelated Diseases. Yelling Stop.

Goodrich, T. (2020b, June 2). Does Consumption of Omega-6 Seed Oils Worsen ARDS and COVID-19? [Blog]. Yelling Stop.

Goodrich, T. D. (2021, July 8). Interview: Thomas Seyfried on Glioblastoma, Metabolic Cancer Breakthroughs, with David Gornoski on A Neighbor’s Choice [Blog]. Yelling Stop.

Gornoski, D. (2021, May 24). Omega 6 Linoleic Acid Research with Prof. Bruce Hammock, Prof. Bruce German, and Tucker Goodrich (No. 5/24/2021) [Mp3].

Gulhane, M. (2023, May 23). Danny Lauria: Recovering from “floxxing” with mitochondrial and circadian practices (No. 25) [Mp3].

Horgan, V. J., Philpot, J. S. L., Porter, B. W., & Roodyn, D. B. (1957). Toxicity of autoxidized squalene and linoleic acid, and of simpler peroxides, in relation to toxicity of radiation. Biochemical Journal, 67(4), 551–558.

Humphries, K. M., & Szweda, L. I. (1998). Selective Inactivation of α-Ketoglutarate Dehydrogenase and Pyruvate Dehydrogenase: Reaction of Lipoic Acid with 4-Hydroxy-2-nonenal. Biochemistry, 37(45), 15835–15841.

Kagan, V. E., Tyurin, V. A., Jiang, J., Tyurina, Y. Y., Ritov, V. B., Amoscato, A. A., Osipov, A. N., Belikova, N. A., Kapralov, A. A., Kini, V., Vlasova, I. I., Zhao, Q., Zou, M., Di, P., Svistunenko, D. A., Kurnikov, I. V., & Borisenko, G. G. (2005). Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors. Nature Chemical Biology, 1(4), Article 4.

Le, H. D., Meisel, J. A., de Meijer, V. E., Fallon, E. M., Gura, K. M., Nose, V., Bistrian, B. R., & Puder, M. (2012). Docosahexaenoic Acid and Arachidonic Acid Prevent Essential Fatty Acid Deficiency and Hepatic Steatosis. Journal of Parenteral and Enteral Nutrition, 36(4), 431–441.

McReynolds, C. B., Cortes-Puch, I., Ravindran, R., Khan, I. H., Hammock, B. G., Shih, P. B., Hammock, B. D., & Yang, J. (2021). Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections. Frontiers in Physiology, 12.

Midtbø, L. K., Ibrahim, M. M., Myrmel, L. S., Aune, U. L., Alvheim, A. R., Liland, N. S., Torstensen, B. E., Rosenlund, G., Liaset, B., Brattelid, T., Kristiansen, K., & Madsen, L. (2013). Intake of farmed Atlantic salmon fed soybean oil increases insulin resistance and hepatic lipid accumulation in mice. PloS One, 8(1), e53094.

Miyamoto, S., Nantes, I. L., Faria, P. A., Cunha, D., Ronsein, G. E., Medeiros, M. H. G., & Di Mascio, P. (2012). Cytochrome c-promoted cardiolipin oxidation generates singlet molecular oxygen. Photochemical & Photobiological Sciences, 11(10), 1536.

Ramsden, C. E., Faurot, K. R., Zamora, D., Suchindran, C. M., MacIntosh, B. A., Gaylord, S., Ringel, A., Hibbeln, J. R., Feldstein, A. E., Mori, T. A., Barden, A., Lynch, C., Coble, R., Mas, E., Palsson, O., Barrow, D. A., & Mann, D. J. (2013). Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: A randomized trial. Pain, 154(11), 2441–2451.

Ramsden, C. E., Hennebelle, M., Schuster, S., Keyes, G. S., Johnson, C. D., Kirpich, I. A., Dahlen, J. E., Horowitz, M. S., Zamora, D., Feldstein, A. E., McClain, C. J., Muhlhausler, B. S., Makrides, M., Gibson, R. A., & Taha, A. Y. (2018). Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in mice. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1863(10), 1206–1213.

Ramsden, C. E., Ringel, A., Feldstein, A. E., Taha, A. Y., MacIntosh, B. A., Hibbeln, J. R., Majchrzak-Hong, S. F., Faurot, K. R., Rapoport, S. I., Cheon, Y., Chung, Y.-M., Berk, M., & Douglas Mann, J. (2012). Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. Prostaglandins, Leukotrienes and Essential Fatty Acids, 87(4), 135–141.

Stanley, W. C., Dabkowski, E. R., Ribeiro, R. F., & O’Connell, K. A. (2012). Dietary Fat and Heart Failure: Moving from Lipotoxicity to Lipoprotection. Circulation Research, 110(5), 764–776.

Taylor, N. W., Sinclair, W. K., & Gorson, R. O. (2004). In Memoriam: Lauriston S. Taylor [Informational]. Health Physics Society.

Tuominen, A., Miller, Y. I., Hansen, L. F., Kesäniemi, Y. A., Witztum, J. L., & Hörkkö, S. (2006). A Natural Antibody to Oxidized Cardiolipin Binds to Oxidized Low-Density Lipoprotein, Apoptotic Cells, and Atherosclerotic Lesions. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(9), 2096–2102.

Vadvalkar, S. S., Matsuzaki, S., Eyster, C. A., Giorgione, J. R., Bockus, L. B., Kinter, C. S., Kinter, M., & Humphries, K. M. (2017). Decreased Mitochondrial Pyruvate Transport Activity in the Diabetic Heart Role of Mitochondrial Pyruvate Carrier 2 (mpc2) Acetylation. Journal of Biological Chemistry, 292(11), 4423–4433.

Wahls, T. L. (2010). Minding My Mitochondria 2nd Edition: How I overcame secondary progressive multiple sclerosis (MS) and got out of my wheelchair. (2nd edition). TZ Press.


Wednesday, May 31, 2023

"Calorie restriction and pravastatin administration during pregnancy in obese rhesus macaques modulates maternal and infant metabolism and infant brain and behavioral development"

"...negative impacts were also found in both mothers and infants. Our study emphasizes the importance of assessing gestational interventions for maternal obesity on both maternal and offspring long-term outcomes."

Link via Taha AY

Tuesday, May 23, 2023

"Neuroprotective effect of herbal extracts inhibiting soluble epoxide hydrolase (sEH) and cyclooxygenase (COX) against chemotherapy-induced cognitive impairment in mice"

Interesting. (The memory-preserving compound is known commercially as "Mentat". Heh.) "Chemotherapy-induced cognitive impairment (CICI) is a novel clinical condition characterized by memory, learning, and motor function deficits. Oxidative stress and inflammation are potential factors contributing to chemotherapy's adverse effects on the brain. Inhibition of soluble epoxide hydrolase (sEH) has been proven effective in neuroinflammation and reversal of memory impairment."

Link via Hammock BD