Friday, March 5, 2021

Podcast Interview (A Twofer!): "The Dangers of Omega 6 Seed Oils" and "Soybean Oil Retardation"

David Gornoski interviewed me not once, but twice recently. A first for me, both of these made it to radio! His show appears on WHBO and WFLA in Florida.

The first interview was on February 27, 2021, and the topic was a familiar one:

"The Dangers of Omega 6 Seed Oils"

Introductory, clearly, but hopefully interesting even if you're familiar with the topic.



Or here, for video:

On March 3 David asked me back to discuss a recent paper:
"Dysregulation of Hypothalamic Gene Expression and the Oxytocinergic System by Soybean Oil Diets in Male Mice" (Deol et al, 2020)
Which was brought to my attention to back in December:
We didn't get into some interesting attributes of this study (like what role linoleic acid actually had) because I wanted to draw attention to some of the previous work this group had done (see citations), leading to my all-time favorite industry rag headline:
"Less Obesity", so they know it causes obesity.

That discussion is here:

The article that spurred the discussing was the EU Times lift of an RT International story (last two citations below), unfortunately I didn't have time to deflate some of the more hyperbolic claims from those two articles: I tried to just stick with the science, which does largely support the hyperbole.

I was introduced to David by Chris Knobbe, MD, so thanks for the introduction, Chris!


Deol, P., Evans, J. R., Dhahbi, J., Chellappa, K., Han, D. S., Spindler, S., & Sladek, F. M. (2015). Soybean Oil Is More Obesogenic and Diabetogenic than Coconut Oil and Fructose in Mouse: Potential Role for the Liver. PloS One, 10(7), e0132672–e0132672. https://doi.org/10.1371/journal.pone.0132672
Deol, Poonamjot, Fahrmann, J., Yang, J., Evans, J. R., Rizo, A., Grapov, D., Salemi, M., Wanichthanarak, K., Fiehn, O., Phinney, B., Hammock, B. D., & Sladek, F. M. (2017). Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice. Scientific Reports, 7(1), 1–13. https://doi.org/10.1038/s41598-017-12624-9
Deol, Poonamjot, Kozlova, E., Valdez, M., Ho, C., Yang, E.-W., Richardson, H., Gonzalez, G., Truong, E., Reid, J., Valdez, J., Deans, J. R., Martinez-Lomeli, J., Evans, J. R., Jiang, T., Sladek, F. M., & Curras-Collazo, M. C. (2020). Dysregulation of Hypothalamic Gene Expression and the Oxytocinergic System by Soybean Oil Diets in Male Mice. Endocrinology. https://doi.org/10.1210/endocr/bqz044
GMO-Sourced Soybean Oil Causes Less Obesity than Conventional Oil. (2017, October 2). GEN - Genetic Engineering and Biotechnology News. https://www.genengnews.com/news/gmo-sourced-soybean-oil-causes-less-obesity-than-conventional-oil/
Soybean Oil Causes Mental Retardation, Autism, Dementia and Alzheimer’s Research Finds. (2020, January 24). [News]. The European Union Times - World News, Breaking News. https://www.eutimes.net/2020/01/soybean-oil-causes-mental-retardation-autism-dementia-and-alzheimers-research-finds/
Would you like brain damage with that? America’s favorite cooking oil causes neurological changes, says animal study. (n.d.). RT International. Retrieved March 3, 2021, from https://www.rt.com/news/479111-soybean-oil-change-mice-brain/

Sunday, February 21, 2021

Seed Oils (Linoleic Acid) and Susceptibility to Burning

This is one of my favorite twitter threads, but twitter is a strange, fluid place, so I thought I would memorialize it here for posterity.

I present the thread first as a narrative; the links to the tweets will appear below, along with the author's information.
Ok, time for a MIND. BLOWN. thread

I was cooking myself lunch just now. I wanted something quick and practical (and meat is always on the menu) so I went for steak and butter on steel pan. About a pound of it.

I'm not a frequent cook so sometimes I mess things up a little.

I was putting away things in the fridge when realized butter was smoking a lot.

I rushed to add the meat, butter splashed and half my thumb got licked by smoking butter (almost 200 C or 350 F)

I had read about @TuckerGoodrich's stories about resistance to sun burn and fire burns when you substitute PUFAs from your diet and my first reaction was confusion:

I very well know what an oil burn feels like and it just didn't hurt as much! Plus, my skin is not even red!

No pain, no redness, no swelling, NADA!

I had already noticed a huge, HUGE difference with my tolerance to sun but this is even crazier!

I'M REALLY IMPRESSED BY THIS!

Of course other factors can't be excluded, such as placebo effect 
😉🙄😂

It's going to take a very, very good reason for me to ever use industrial PUFA oils in my kitchen again.

Funny thing is it's a bit awkward to even talk to people about this. People will surely think I'm crazy (or a quack)....

I'm telling you guys, @TuckerGoodrich is right on to something huge with potencially deep implications for health in general.

Someone has to give this a shot in formal research.

Great stuff. Exciting times

All thanks to Twitter. I would never have known about this anywhere else in a hundred times.

Plus people who are willing to direct you towards links, references and awesome discussions.

Fire-resistance, by diet!

I'm really blown away! Say what you will, quack or not.

End of thread.

Please somehow try this (SAFELY) at home!

Here's his twitter profile:

Guilherme Marquezine

And below are the tweets. Pretty cool.


Wednesday, February 17, 2021

Podcast Interview: "A Cautionary, Fascinating Tale of How So-called 'Heart Healthy' Seed Oils Can Make Us Sick" with Susan Flory.

Susan Flory
Susan Flory

A really nice interview with Susan Flory, whose "The Big Middle" podcast is about "Free-range conversations about living healthier for longer and demanding more from the bigger middle of life"

A cautionary, fascinating tale of how so-called 'heart healthy' seed oils can make us sick

On this episode of The Big Middle, the compelling case against seed and vegetable oils still being touted as ‘heart-healthy’. Those bottles of chemically-extracted fat that take up entire aisles of grocery stores are increasingly seen as hazardous to our health – key drivers of autoimmunity, macular degeneration and the modern plague of lifestyle diseases known as metabolic syndrome.

Even the major makers of soybean, sunflower, corn and other seed and vegetable oils are quietly backing away from them, well aware of the biological damage they can do.

Tucker Goodrich has been sounding the alarm over the health risks of seed oils for more than a decade. He suffered 20 years of gastrointestinal torment and much – scary – more that mystified his doctors. So he dug into the medical science himself, eventually pinpointing industrial seed oils as a villain in his sickness puzzle.

Tucker’s become a recognised world authority on the subject and I guarantee his Patient Heal Thyself story will blow your mind...

The podcast is here, with the usual subscription options, or listen below.



Also, we discuss this: Stephan Guyenet's "Malocclusion: Disease of Civilization" Series, if you want more information.

Stephan Guyenet's "Malocclusion: Disease of Civilization" Series.

 When Justin Owings posted a link to one of the posts in Stephan Guyenet's series*, he couldn't possibly have imagined the effect it would have on my life.

As someone who had stopped eating sugar in hopes it would have a beneficial effect on cavities (it did) I was primed for the message of this series, but I couldn't have imagined the effect it would ultimately have on me.

Since I mention it regularly, I thought I would provide links to the entire series, as it's been someone buried in the mists of time in the internet (it's from 2009!).

Enjoy!

  1. "Malocclusion: Disease of Civilization"
    "In his epic work Nutrition and Physical Degeneration, Dr. Weston Price documented the abnormal dental development and susceptibility to tooth decay that accompanied the adoption of modern foods in a number of different cultures throughout the world. Although he quantified changes in cavity prevalence (sometimes finding increases as large as 1,000-fold), all we have are Price's anecdotes describing the crooked teeth, narrow arches and "dished" faces these cultures developed as they modernized.

    "Price published the first edition of his book in 1939. Fortunately, 
    Nutrition and Physical Degeneration wasn't the last word on the matter. Anthropologists and archaeologists have been extending Price's findings throughout the 20th century. My favorite is Dr. Robert S. Corruccini, currently a professor of anthropology at Southern Illinois University. He published a landmark paper in 1984 titled "An Epidemiologic Transition in Dental Occlusion in World Populations" that will be our starting point for a discussion of how diet and lifestyle factors affect the development of the teeth, skull and jaw (Am J. Orthod. 86(5):419)*....

    "...Over the course of the next several posts, I'll give an overview of the extensive literature showing that hunter-gatherers past and present have excellent occlusion, subsistence agriculturalists generally have good occlusion, and the adoption of modern foodways directly causes the crooked teeth, narrow arches and/or crowded third molars (wisdom teeth) that affect the majority of people in industrialized nations. I believe this process also affects the development of the rest of the skull, including the face and sinuses.

  2. "Malocclusion: Disease of Civilization, Part II"

  3. "Malocclusion: Disease of Civilization, Part III"

  4. "Malocclusion: Disease of Civilization, Part IV"

  5. "Malocclusion: Disease of Civilization, Part V"

  6. "Malocclusion: Disease of Civilization, Part VI"

  7. "Malocclusion: Disease of Civilization, Part VII"

  8. "Malocclusion: Disease of Civilization, Part VIII"

  9. "Malocclusion: Disease of Civilization, Part IX"

    "A Summary

    "For those who didn't want to wade through the entire nerd safari, I offer a simple summary.

    "Our ancestors had straight teeth, and their wisdom teeth came in without any problem. The same continues to be true of a few non-industrial cultures today, but it's becoming rare. Wild animals also rarely suffer from orthodontic problems.

    "Today, the majority of people in the US and other affluent nations have some type of malocclusion, whether it's crooked teeth, overbite, open bite or a number of other possibilities...."

    Two identical twins, the only difference is in dental treatment. From post IX.




* Whole Health Source was Stephan's original site, which he's (mostly) left up as it was. All these articles were posted there. His new site is here.

Saturday, February 6, 2021

Podcast Interview: "Dr. Cate Shanahan & Tucker Goodrich on the True Cause of Disease and How We Know This" with Brian Sanders


Excellent discussion with Dr. Cate Shanahan and Brian Sanders. Very fun!
"Today is a special show that I really enjoyed with 2 guests - Dr. Cate Shanahan and Tucker Goodrich. I had Tucker on years ago for episode 20 and he laid out the entire case against seed oils which was very compelling. Dr. Cate has been on twice already (more recently) and is a wealth of knowledge on many, many things, especially the dangers of seed oils and reinforcing the Sapien diet concepts. We cover how people get fat & sick all the way down to the mitochondrial level. We discuss the different players in this process including seed oils (or more specifically excess amounts of omega-6), refined grains, and sugar.

"We also do my favorite thing and look at all sides of the arguments. We use an article a seed oil supporter wrote as a tool to check in on the studies and claims cited. You won’t want to miss this one! It’s a long one, but we cover a lot, and there’s a bunch of great new info....
Follow the link above for the whole thing.

Sunday, January 24, 2021

Comments

 After marveling that almost no-one ever comments on my blog, I've just noticed that there are loads "pending moderation".

Not quite sure what is going on, as I've not been receiving notifications for these, but I'll go through them.

Of course some junk spam comments have gotten through.

Typical Google software.

Thursday, January 21, 2021

Interesting Study: "Effect of a Plant-Based, Low-Fat Diet versus an Animal-Based, Ketogenic Diet on Ad Libitum Energy Intake"

This is from Kevin Hall, who's a very polarizing figure in the LCHF/Keto diet community, and will be even more so after this!
"The carbohydrate–insulin model of obesity posits that high-carbohydrate diets lead to excess insulin secretion, thereby promoting fat accumulation and increasing energy intake. Thus, low-carbohydrate diets are predicted to reduce ad libitum energy intake as compared to low-fat, high-carbohydrate diets....
"The primary outcomes compared mean daily ad libitum energy intake between each 2-week diet period as well as between the final week of each diet. We found that the low-fat diet led to 689 ± 73 kcal d−1 less energy intake than the low-carbohydrate diet over 2 weeks (P < 0.0001) and 544 ± 68 kcal d−1 less over the final week (P < 0.0001). Therefore, the predictions of the carbohydrate–insulin model were inconsistent with our observations."

"Figure 3. Body weight and composition changes.
A) Both the ABLC and PBLF diets led to progressive
weight loss over time with the ABLC diet resulting
in more rapid weight loss during the first week.
B) Fat-free mass decreased significantly
only during the ABLC and accounted for the majority
of the observed weight loss. C) Body fat mass decreased
with the PBLF diet but was not significantly
decreased with the ABLC diet."
The Keto diet people lost more weight, but it was "fat-free" weight, which in this case means water. (ABLC = Animal-Based, Low Carbohydrate; PBLF = Plant-Based, Low-Fat.)

"Despite the substantial differences in energy intake between the PBLF and ABLC diets, total weight loss after two weeks was surprisingly similar. Greater weight loss during the first week of the ABLC diet as compared to the PBLF diet was likely due to differences in body water, glycogen, and gastrointestinal contents. Indeed, fat-free mass was decreased significantly with the ABLC diet whereas fat-free mass was relatively preserved with the PBLF diet."

Surprisingly, "Only the PBLF diet led to a significant body fat loss."

So the keto diet "won", but not in a meaningful way, as the knock on the LCHF diet has long been that the weight loss was water loss, and not really fat loss—which is of course what you want!

I have personally been on an intermittent keto diet for going on 10 years now. I can assure you that the initial weight loss was not water loss, as I've managed to maintain it for these 10 years. I've coached people who've seen significant weight loss, in one case 56 pounds over 10 weeks, which has so far also stayed off.

So these results don't reflect my experience.

But Hall structured this as a test of what's known as the Carbohydrate/Insulin Model of obesity, in other words that carbohydrate causes a rise in insulin, which causes fat accumulation. The CIM took a bit of a beating here, as indeed they had higher insulin, but they also ate less, without feeling hungry, and lost more fat.

I think that a ketogenic diet is the most efficient way to lose weight, but I don't think that our obesity epidemic is the result of eating carbohydrates. My hypothesis is that it's omega-6 fats that are the culprit.

Well, luckily the "underperforming" keto diet in this study was not one that I eat myself, or that I would recommend someone else eat. 


This study really wasn't testing this hypothesis, but it happens that the seemingly underperforming ABLC diet was 15% (by energy) n-6 PUFA, while the PBLF diet was less than 3%. The reigning animal model for inducing obesity used 8% energy as n-6 PUFA (more about that in a future post).

So while a lot of LCHF advocates who think it's carbohydrate that is driving the obesity epidemic are a bit disgruntled with this paper, I'm happy to see that Hall didn't gore my ox!

Yet.




NB: I was working off a pre-print version of this paper. I may have to revise this post if it winds up that the published version is wildly different.

Goodrich, T. (2017, November 9). Omega-6 Fats: The Alternative Hypothesis for Chronic Disease. Yelling Stop. http://yelling-stop.blogspot.com/2017/11/omega-6-fats-alternative-hypothesis-for.html
Hall, K. D., Guo, J., Courville, A. B., Boring, J., Brychta, R., Chen, K. Y., Darcey, V., Forde, C. G., Gharib, A. M., Gallagher, I., Howard, R., Joseph, P. V., Milley, L., Ouwerkerk, R., Raisinger, K., Rozga, I., Schick, A., Stagliano, M., Torres, S., … Chung, S. T. (2021). Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake. Nature Medicine, 1–10. https://doi.org/10.1038/s41591-020-01209-1