Friday, April 9, 2021

Podcast Interview: "Using a Clean Diet to Address Chronic Illness", Fitness Confidential with Vinnie Tortorich

Vinnie was kind enough to have me back on his show.

"On this Friday show, Tucker Goodrich joins Vinnie to talk his health issues, how he is using a clean diet to address so many of them, helping your family members, diet lies, and more."

We talked about how important motivation is for success, as I learned with my father who died last September. Vinnie discussed how he was able to help his parents. 

A tough discussion, on a topic I haven't really gotten into before.

Vinnie's got a number of projects going, including a movie he released (links at his site).

I reviewed his book a couple of years ago, that is here:

"Review: "Fitness Confidential" by Vinnie Tortorich"

H7N9 Influenza Vaccine Trial: Being a Guinea Pig for Science

So I came across a COVID-19 Vaccine Trial:

"Velocity Clinical Research... is looking for healthy participants that have a passion for research and a dedication to help fight COVID. We have a phase 1 COVID-19 vaccine trial... This vaccine is created using a plant based approach."

That was interesting, so I signed up. The ad I saw didn't mention the age range, which was 18 to 49, so, being 53, I didn't qualify.

As a consolation prize, the fellow who contacted me said they were doing a trial on a bird flu vaccine, for which I qualified.

OK, so I signed up for that one instead.

Probably a good thing that I wasn't getting a "plant based" COVID-19 vaccine, whatever the heck that means!

"All adjuvanted vaccines met regulatory acceptance criteria. In groups receiving adjuvanted formulations, seroconversion rates were ≥85.7%, seroprotection rates ≥91.1%, and geometric mean titers ≥92.9% versus 23.2%, 28.6%, and 17.2 for the nonadjuvanted vaccine. The AS03 adjuvant enhanced immune response at antigen-sparing doses. Injection site pain occurred more frequently with adjuvanted vaccines (in ≤98.3% of vaccinees) than with the nonadjuvanted vaccine (40.7%) or placebo (20.0%). None of the 20 serious adverse events reported were related to vaccination."

Well, I'm not suicidal, or a masochist, so this looked reasonable to see from the inside what a vaccine trial looks like.

This is a seriously dangerous virus, compared to SARS-CoV-2.  It's far less contagious, so far, but far more lethal, with a case fatality rate in the 40% range. Yikes! Up until 2020, this was considered one of the prime candidates for a serious pandemic virus, which is why they are developing a vaccine for it.

The trial I seem to be in is this one:

"A Study to Evaluate the Safety and Immunogenicity of GlaxoSmithKline Biologicals' Influenza Vaccine GSK3206641A Administered in Adults 18 to 64 Years of Age and 65 Years of Age and Older."

I say "seem" because at the time I went to the office and found out the details (April 7), this study was listed as "not recruiting", which surprised the physician who saw me, as she said it had been recruiting for a while. It was updated yesterday, however, and now says it is recruiting guinea pigs. Typical bureaucratic SNAFU, in other words. The information that Velocity provided to me suggested going to the clinicaltrials.gov site to look up the details, but didn't provide any information by which one could identify the trial. However this is the only one listed for H7N9. Sigh. 

At any rate, they were all quite surprised that I had actually looked up the trial, and had read the results of the previous trial, and was fully briefed on what was going on. I guess no one does this.

Dry hole.
So I went to the office on the 7th and went through the process. 

  1. Fill out the paperwork, including a medical history, read the disclaimer information and then go through the process of them making sure I'm actually willing to be a guinea pig.
  2. Answer some further questions about my medical history, and get a basic physical. I'm apparently quite healthy, and, most importantly, have no auto-immune diseases, and am not on any immune-suppressing drugs, which I gather would have been disqualifying. Allergies and asthma don't count.
  3. Get a blood draw. Took three tries to get a good draw, but I think the first person to try this wasn't too good at it, the second person had no problem.
  4. Get the vaccine. There are 7 arms to this trial, and only one is the placebo, so it's an 86% chance (6 in 7) that I got something injected.
  5. Go sit in the observation room to see if I grow a third arm or something.
Much to my surprise, I did have a little bit of a reaction to the shot. They injected the vaccine (86% likely) into my right deltoid (shoulder) muscle, and shortly thereafter, I got a mild shooting pain lower down in my arm. I got a few more joint pains around my body, but most noticeable, I got pretty spacey. Not dizzy, but spaced out.

So the physician came out and chatted with me for a few minutes, and decided I was well enough, and sent me on my way. I stopped by a store, and forgot my phone number. Whoops!

But I was well enough. Got a tiny bit of a headache too, but that went away quickly enough.

Running cures what ails you!
Went for a run in the afternoon, and was fine after that.

The joint pains and headache are expected reactions to the injection, btw, so no worries so far.

So now I have to keep a diary each day, and take my temperature—they gave me a digital thermometer for this, which is good, because I don't know where mine is.

Oddly, my temperature has been just above 99F, including before they gave me the shot. 100.4F was their cutoff for a fever, so that didn't disqualify me.

No reaction at the injection site, it's just a tiny bit sore if I press on it, which is typical for any vaccination, but not nearly so bad as a tetanus shot, for instance.

No reactions at all after the first day.

Study protocol. They skipped the pregnancy test.
I have to keep the diary for seven days, then go back for a second shot in a couple of weeks, then follow up by phone to see if I'm still alive for several months after that. The whole trial lasts 13 months.

Oh, they do pay a nominal amount for participating in the trial, and they will cover your medical expenses if you get sick from the shot.

This also means that I am not allowed to get a COVID-19 vaccination for a couple of months, as that would ruin this experiment.

Since I was already either infected or exposed to COVID, I'm not worried about that, especially since the risk to me of being seriously ill with COVID is minute.

Amusingly, they gave me a COVID-19 surveillance form, to see if I come down with COVID-19.

"But the symptoms are the same as the flu", I observed.

"Yes, we know."

So I'll find out in 13 months what they did to me.

Friday, April 2, 2021

What Causes Heart Disease, LDL or Seed Oils?

Hat tip to Dave Feldman for calling my attention to this podcast: Which sounded interesting, so I downloaded it to listen to on my morning run.

Given the comment by the interviewer, I had been hoping to get farther than a few minutes into my run before having to stop and tweet!

So to be correct, what he says (LDL is the "genetic", "primary cause" of CVD) is what got me. This can only be said by relying on a subset of the science, not, as the interviewer says, "the science".

But let's let Professor Packard put it in his own words (all transcriptions are mine, as are any errors therein. These are all taken from the tweet thread starting with my retweet above.).

He's discussing LDL, and a sub-type of LDL, Lp(a), which is a sub-type of oxidized LDL (oxLDL). He mentions that Lp(a) can be reduced by niacin (nicotinic acid), but that:

"...was put aside because of the THRIVE trial..." 

Huh, so what's the THRIVE trial?

"...participants who were assigned to extended-release niacin–laropiprant had an LDL cholesterol level that was an average of 10 mg per deciliter (0.25 mmol per liter as measured in the central laboratory) lower..."

So if you think LDL causes CVD, then a reduction of LDL must be a good thing, right? Unfortunately, the THRIVE trial was a "failed" trial, one which failed to show a benefit:

"...Among participants with atherosclerotic vascular disease, the addition of extended-release niacin–laropiprant to statin-based LDL cholesterol–lowering therapy did not significantly reduce the risk of major vascular events..."
So LDL is a "genetic" "primary cause" except when it has no effect whatsoever, apparently.

"Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients"

Niacin also reduced Lp(a), among other seemingly beneficial things, "...lowering triglyceride and lipoprotein(a) levels and blood pressure." But all was for naught.

It's an odd cause, in my simple engineering view, that is only occasionally causal, as this is not the first time that reducing LDL has failed to show a benefit for CVD.

Next we come to this:
"...the classic exception is the guy in the [NEJM] who ate 40 eggs a day... and never got any problems with his LDL cholesterol... "
Seriously? We're back to eggs causing heart disease? This is the expert? This was considered debunked in the 1950s, for heaven's sake.
Even the Dietary Guidelines dropped the recommendation against dietary cholesterol for lack of evidence.

"Normal Plasma Cholesterol in an 88-Year-Old Man Who Eats 25 Eggs a Day"

So ponder this: 
"LDL cholesterol is a marker of nutrition. So, that if you have a very poor diet, or you have existing disease, then you'll have a low LDL cholesterol."

Well, I agree with Prof. Packard! In fact, one of my major arguments for avoiding seed oils is the fact that they lower cholesterol, which seems to correlate with their negative effects on heart disease. 

So one would logically conclude a diet change that raised LDL would be good, and one that lowered it (like seed oils) would be bad, right?

He continues: 

"With the canakinumab trial we had a proof of concept, and absolutely correct that Paul [Ridker]... showed that lowering inflammation gave rise to a benefit [in CVD] without a reduction in LDL. And that does suggest that if you target the correct pathway, the correct inflammatory pathway, which is the IL-1β / IL-6 pathway... you end up probably stopping LDL having it's deleterious effects."
We won't get too into the details there, suffice to say that drug stops a cytokine from being produced, and this has a benefit for CVD that does not depend on LDL reduction. 

Now how could we do that to prevent people from getting CVD in the first place?

"The induction of [IL-1β] release from human monocyte-derived macrophages by 9-HODE and cholesteryl-9-HODE suggests a role for modified LDL, and its associated [linoleic acid] oxidation products, in vascular smooth muscle cell proliferation."

That's from 1992, which is shortly after it was shown that LDL alone did not induce the first step of atherosclerosis, it had to be "modified". The modification, it turned out, was the inclusion of linoleic acid from dietary seed oils, which would then become oxidized, and thus pathological, inducing the first step of atherosclerosis—and the rest, IMHO, and as suggested by the canakinumab trial.

"Induction of interleukin 1 beta expression from human peripheral blood monocyte-derived macrophages by 9-hydroxyoctadecadienoic acid."

So after assuring us that LDL is causal, Prof. Packard goes on to demonstrate, from the science, that it is not.

Yes, stop eating the precursor that causes that harmful inflammation, linoleic acid. 

Fix your poor diet: eat no seed oils

Don't worry about LDL.

Here's that podcast.

Listen to Prof. Packard explain (unwittingly) how a low seed oil diet could allow you to stop worrying about your LDL.



Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients. (2014). New England Journal of Medicine, 371(3), 203–212. https://doi.org/10.1056/NEJMoa1300955
Kern, F. (1991). Normal Plasma Cholesterol in an 88-Year-Old Man Who Eats 25 Eggs a Day. New England Journal of Medicine, 324(13), 896–899. https://doi.org/10.1056/NEJM199103283241306
Ku, G., Thomas, C. E., Akeson, A. L., & Jackson, R. L. (1992). Induction of interleukin 1 beta expression from human peripheral blood monocyte-derived macrophages by 9-hydroxyoctadecadienoic acid. Journal of Biological Chemistry, 267(20), 14183–14188. https://doi.org/10.1016/S0021-9258(19)49695-6
Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., Kastelein, J. J. P., Cornel, J. H., Pais, P., Pella, D., Genest, J., Cifkova, R., Lorenzatti, A., Forster, T., Kobalava, Z., … Glynn, R. J. (2017). Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease. New England Journal of Medicine, 377(12), 1119–1131. https://doi.org/10.1056/NEJMoa1707914
Witztum, J. L., & Steinberg, D. (1991). Role of oxidized low density lipoprotein in atherogenesis. Journal of Clinical Investigation, 88(6), 1785–1792. https://doi.org/10.1172/JCI115499

Podcast Interview: Seed Oil Madness with Tucker Goodrich! on Boundless Body Radio with Casey Ruff.

Listen here.
A very fun discussion with Casey Ruff of Boundless Body Radio:

"They are SEED OILS, not vegetable oils, and they are TOXIC. Tucker Goodrich is a warrior against this horrible sludge that is destroying people's health. He is a technology expert who designs, runs, and debugs complex systems in high-risk financial environments. When his health failed him, he started investigating in the same way that he TAUGHT HIMSELF how to manage large, complex software systems by looking at the data, and realized that oxidized vegetable oils were ubiquitously everywhere, and needed to be removed. His health has flourished ever since, and he continues to share his message. We are so grateful for Tucker Goodrich and his message, and we are STOKED that he took the time to speak with us today!"
(I tried to embed the player, which didn't work too well! LOL. Follow the link above to listen or subscribe.)

Saturday, March 27, 2021

Podcast Interview: The Dangers of Seed Oils Part II: Tucker Goodrich Returns with David Gornoski

David Gornoski interviewed me again:

"The Dangers of Seed Oils Part II: Tucker Goodrich Returns with David Gornoski"
"Nutritional researcher Tucker Goodrich returns for another conversation with David Gornoski. The two build on their previous conversation on the harmful effects of PUFAs, the kinds of animal fats our bodies can tolerate, the dangers of soybean oils, the reason for cancer rates going up, ancestral diet, and more. What is oxidation? What kinds of seafood can our bodies tolerate? What is the most effective way of losing weight? Listen to the full podcast to find out."

Or Youtube (where you can see what six hours of sun does to my face!):

 

Friday, March 5, 2021

Podcast Interview (A Twofer!): "The Dangers of Omega 6 Seed Oils" and "Soybean Oil Retardation"

David Gornoski interviewed me not once, but twice recently. A first for me, both of these made it to radio! His show appears on WHBO and WFLA in Florida.

The first interview was on February 27, 2021, and the topic was a familiar one:

"The Dangers of Omega 6 Seed Oils"

Introductory, clearly, but hopefully interesting even if you're familiar with the topic.



Or here, for video:

On March 3 David asked me back to discuss a recent paper:
"Dysregulation of Hypothalamic Gene Expression and the Oxytocinergic System by Soybean Oil Diets in Male Mice" (Deol et al, 2020)
Which was brought to my attention to back in December:
We didn't get into some interesting attributes of this study (like what role linoleic acid actually had) because I wanted to draw attention to some of the previous work this group had done (see citations), leading to my all-time favorite industry rag headline:
"Less Obesity", so they know it causes obesity.

That discussion is here:

The article that spurred the discussing was the EU Times lift of an RT International story (last two citations below), unfortunately I didn't have time to deflate some of the more hyperbolic claims from those two articles: I tried to just stick with the science, which does largely support the hyperbole.

I was introduced to David by Chris Knobbe, MD, so thanks for the introduction, Chris!


Deol, P., Evans, J. R., Dhahbi, J., Chellappa, K., Han, D. S., Spindler, S., & Sladek, F. M. (2015). Soybean Oil Is More Obesogenic and Diabetogenic than Coconut Oil and Fructose in Mouse: Potential Role for the Liver. PloS One, 10(7), e0132672–e0132672. https://doi.org/10.1371/journal.pone.0132672
Deol, Poonamjot, Fahrmann, J., Yang, J., Evans, J. R., Rizo, A., Grapov, D., Salemi, M., Wanichthanarak, K., Fiehn, O., Phinney, B., Hammock, B. D., & Sladek, F. M. (2017). Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice. Scientific Reports, 7(1), 1–13. https://doi.org/10.1038/s41598-017-12624-9
Deol, Poonamjot, Kozlova, E., Valdez, M., Ho, C., Yang, E.-W., Richardson, H., Gonzalez, G., Truong, E., Reid, J., Valdez, J., Deans, J. R., Martinez-Lomeli, J., Evans, J. R., Jiang, T., Sladek, F. M., & Curras-Collazo, M. C. (2020). Dysregulation of Hypothalamic Gene Expression and the Oxytocinergic System by Soybean Oil Diets in Male Mice. Endocrinology. https://doi.org/10.1210/endocr/bqz044
GMO-Sourced Soybean Oil Causes Less Obesity than Conventional Oil. (2017, October 2). GEN - Genetic Engineering and Biotechnology News. https://www.genengnews.com/news/gmo-sourced-soybean-oil-causes-less-obesity-than-conventional-oil/
Soybean Oil Causes Mental Retardation, Autism, Dementia and Alzheimer’s Research Finds. (2020, January 24). [News]. The European Union Times - World News, Breaking News. https://www.eutimes.net/2020/01/soybean-oil-causes-mental-retardation-autism-dementia-and-alzheimers-research-finds/
Would you like brain damage with that? America’s favorite cooking oil causes neurological changes, says animal study. (n.d.). RT International. Retrieved March 3, 2021, from https://www.rt.com/news/479111-soybean-oil-change-mice-brain/

Sunday, February 21, 2021

Seed Oils (Linoleic Acid) and Susceptibility to Burning

This is one of my favorite twitter threads, but twitter is a strange, fluid place, so I thought I would memorialize it here for posterity.

I present the thread first as a narrative; the links to the tweets will appear below, along with the author's information.
Ok, time for a MIND. BLOWN. thread

I was cooking myself lunch just now. I wanted something quick and practical (and meat is always on the menu) so I went for steak and butter on steel pan. About a pound of it.

I'm not a frequent cook so sometimes I mess things up a little.

I was putting away things in the fridge when realized butter was smoking a lot.

I rushed to add the meat, butter splashed and half my thumb got licked by smoking butter (almost 200 C or 350 F)

I had read about @TuckerGoodrich's stories about resistance to sun burn and fire burns when you substitute PUFAs from your diet and my first reaction was confusion:

I very well know what an oil burn feels like and it just didn't hurt as much! Plus, my skin is not even red!

No pain, no redness, no swelling, NADA!

I had already noticed a huge, HUGE difference with my tolerance to sun but this is even crazier!

I'M REALLY IMPRESSED BY THIS!

Of course other factors can't be excluded, such as placebo effect 
😉🙄😂

It's going to take a very, very good reason for me to ever use industrial PUFA oils in my kitchen again.

Funny thing is it's a bit awkward to even talk to people about this. People will surely think I'm crazy (or a quack)....

I'm telling you guys, @TuckerGoodrich is right on to something huge with potencially deep implications for health in general.

Someone has to give this a shot in formal research.

Great stuff. Exciting times

All thanks to Twitter. I would never have known about this anywhere else in a hundred times.

Plus people who are willing to direct you towards links, references and awesome discussions.

Fire-resistance, by diet!

I'm really blown away! Say what you will, quack or not.

End of thread.

Please somehow try this (SAFELY) at home!

Here's his twitter profile:

Guilherme Marquezine

And below are the tweets. Pretty cool.