Wednesday, April 14, 2021

H7N9 Influenza Vaccine Trial: Follow-up 1

 So I tracked my symptoms (or lack thereof) for seven days, today is day eight. After the initial, mild symptoms, nothing happened, and happily, nothing continues to happen.

The slight elevation in body temp I had before getting the shot continued for a couple of days, and then disappeared. Although I haven't hit 98.6F at any reading!

I'm due to get the second shot in a couple of weeks, so will post another update then.

Original post: "H7N9 Influenza Vaccine Trial: Being a Guinea Pig for Science"

Tuesday, April 13, 2021

Miki Ben Dor: "The Complete and Unifying Explanation of Human Evolution"

I agree with everything he writes here.


To date, no complete evolutionary explanation has been given for the formation of the human species, and certainly not a complete and unifying explanation at the same time.

An evolutionary explanation explains a physiological or behavioral phenomenon in a species and is complete when it includes a description of adaptability to a defined ecological change. A unifying explanation explains several phenomena as a result of a single reason, as, for example, a description of many geological phenomena as a result of the displacement of tectonic plates (displacement of continents).

In a series of four scientific articles published at the end of 2020 and throughout 2021, all of them together with my partner at Tel Aviv University, Prof. Ran Barkai, we laid out the basis for the explanation and the complete and unifying evolutionary explanation for the formation of the human lineage leading to the Homo sapiens species. We explained many of the significant phenomena in human prehistory, such as increased brain volume, language development, changes in stone tools, and more.

The purpose of the post is to present a concise description of the explanation.

Read the whole thing.

Casey Ruff recently interviewed Miki on this topic, it was a really excellent interview. I especially enjoyed his comments on anthropologists and the Paleo Diet at the end. 

Monday, April 12, 2021

Podcast Interview: "The Destructive Power of Vegetable Seed Oils", dLife.in Podcast with Shashikant Iyengar

 So this was a first, and quite interesting. 

dLife.in is an Indian low-carb diabetes group, founded by Anup Singh—an engineer, natch—who was recently recognized as an "Icon of India" for his work with this group.

Icons Of India Award From Outlook Group
"dLife.in came into existence on the 21st Of August, 2014, as a forum. This was, and always will be, dedicated to promoting “Low Carb High Fat (LCHF)” diet for managing metabolic syndrome disorders like Type 2 Diabetes, Obesity, PCOS, Insulin Resistance, Hypertension, etc. In short, we called it “of, by and for Indians” as the animal protein-centric western low-carb diet was not easy to follow, given the low per-capita animal protein consumption in the subcontinent."

(That video is here, but he discussion is in Hindi...

Best quote: “Engineering is an exact science and engineers are inherently trained to be problem solvers.”

Probably why engineers keep discovering how to treat diabetes while physicians remain clueless.)

Being asked to discuss the issue of seed oils by an Indian group was really an honor, and a bit of a challenge, as seed oils are a long-standing part of Indian culture and diet. Diabetes was first described and diagnosed in India:

"Around the 5th century BC, the famous Indian surgeon Sushruta, in his work Samhita, identified diabetes, by using the term madhumeha (honey-like urine) and pointed out not only the sweet taste of the urine but also its sticky feeling to the touch and its ability to attract the ants (!). Sushruta further mention that diabetes affects primarily the rich castes and is related to the excessive food consumption as the rice, cereals and sweets[6]." (Karamanou et al, 2016)

The consumption of seed oils has been linked to disease in India for some time, prior to the current recognition that the consumption of saturated fat is probably not to blame, and that dairy fat is protective (Mozaffarian et al, 2014):

"Our data, however, do not support this association of high fat intake with the liability to develop ischemic heart disease, because while in the north the consumption of fats, most of which are animal fats, is 19 times more than in the south (Indian Council of Medical Research, 1964), the disease is 7 times less in the north than in the south. Moreover, while the milk fats eaten in the north have a preponderance of saturated fatty acids, the seed oils used in the south are mainly composed of unsaturated fatty acids (Indian Council of Medical Rsearch [sic], 1963)." (Malhotra, 1967)

Shashi sent me an excellent list of questions, and we made good progress in getting through the topic during the Zoom session. 

  • Please tell us about yourself. Your background
  • How come you gained so much knowledge on Seed oils?
  • Please tell us about your personal journey. What were all the ailments you were suffering & how come you identified it and took action
  • Please tell us how these seed oils are harmful / What’s issue with the usage of these seed oils
  • How does these seed oils affect the mitochondria / Electron chain transport?
  • What happens when these oils are heated at high temperature?
  • What are all the ailments caused by excess Linoleic acid
  • Does excess LA cause IR independently
  • What’s the optimal level of Omega3:Omega 6? How has this changed?
  • What’s the issue with the refining process that’s carried out with these seed oils
  • How does excess linoleic acid cause damages to our DNA
  • Can these excess oils which we take be burnt as energy?
  • Does it accumulate in our body? If so how do we eliminate these?
  • How long does it take to clean up our system of the excess LA stores
  • These oils reduce LDL. So how is it bad?
  • How deep has these seed oils penetrated our food supplies
  • How much has the % of Linoleic increased in human consumption in the last decade or 2
  • What are the safest oils / cooking fats we can use?
  • India has some oils as traditional oils- Groundnut or also called as Peanut oil, Sesame oil or mustard oils. How are these if we use cold pressed oils?
  • About S L Malhotra Indian Railway study & the learning from this study.
  • Your view about india and its status as the diabetes capital or on its way from No2 to No1 in times to come
  • Your message to India

We discussed some of the findings about how a change in the use of dietary fats could benefit India specifically, where other interventions are not practical, due to the long-standing traditions of the country.

"In conclusion, the results of this 6-month randomized intervention trial provide evidence that use of olive and canola oils (rich in MUFAs and having a balanced n-6/n-3 PUFAs ratio) as a cooking medium resulted in a significant reduction in fatty liver severity and liver span in NAFLD. Improvement of fatty liver was accompanied by amelioration in insulin resistance and dyslipidemia. All together, these beneficial changes may also decrease the risk for developing type 2 diabetes mellitus and cardiovascular disease in Asian Indians predisposed to develop these diseases." (Nigam et al, 2014)
There was a Q&A at the end, which was a first for me, as was waking up at 3:30 AM MDT for a 5:00AM interview!

Thank you very much to all involved for such a productive discussion!



Some links to studies discussed, below.




Das, S. (2001). Susruta, the pioneer urologist of antiquity. The Journal of Urology, 165(5), 1405–1408.
Ghosh, S., Qi, D., An, D., Pulinilkunnil, T., Abrahani, A., Kuo, K.-H., Wambolt, R. B., Allard, M., Innis, S. M., & Rodrigues, B. (2004). Brief episode of STZ-induced hyperglycemia produces cardiac abnormalities in rats fed a diet rich in n-6 PUFA. American Journal of Physiology. Heart and Circulatory Physiology, 287(6), H2518-2527. https://doi.org/10.1152/ajpheart.00480.2004
Henderson, G. (2016). The Minnesota Coronary Experiment re-analysis by Ramsden et al is a wake-call to re-evaluate the use of polyunsaturated oils and spreads in modern clinical diets? BMJ, i1246.
Karamanou, M., Protogerou, A., Tsoucalas, G., Androutsos, G., & Poulakou-Rebelakou, E. (2016). Milestones in the history of diabetes mellitus: The main contributors. World Journal of Diabetes, 7(1), 1–7. https://doi.org/10.4239/wjd.v7.i1.1
Malhotra, S. L. (1967). Epidemiology of ischaemic heart disease in India with special reference to causation. British Heart Journal, 29(6), 895–905.
Mozaffarian, D., Cao, H., & Hotamisligil, G. S. (2014). Use of trans-palmitoleate in identifying and treating metabolic disease (United States Patent No. US8889739B2). https://patents.google.com/patent/US8889739B2/en
Nigam, P., Bhatt, S., Misra, A., Chadha, D. S., Vaidya, M., Dasgupta, J., & Pasha, Q. M. A. (2014). Effect of a 6-Month Intervention with Cooking Oils Containing a High Concentration of Monounsaturated Fatty Acids (Olive and Canola Oils) Compared with Control Oil in Male Asian Indians with Nonalcoholic Fatty Liver Disease. Diabetes Technology & Therapeutics, 16(4), 255–261. https://doi.org/10.1089/dia.2013.0178
Ramsden, C. E., Zamora, D., Faurot, K., Majchrzak, S., & Hibbeln, J. (2013). The Sydney Diet Heart Study: A randomised controlled trial of linoleic acid for secondary prevention of coronary heart disease and death. The FASEB Journal, 27(S1), 127.4-127.4. https://doi.org/10.1096/fasebj.27.1_supplement.127.4
Ramsden, C. E., Zamora, D., Majchrzak-Hong, S., Faurot, K. R., Broste, S. K., Frantz, R. P., Davis, J. M., Ringel, A., Suchindran, C. M., & Hibbeln, J. R. (2016). Re-evaluation of the traditional diet-heart hypothesis: Analysis of recovered data from Minnesota Coronary Experiment (1968-73). BMJ, 353. https://doi.org/10.1136/bmj.i1246

Friday, April 9, 2021

Podcast Interview: "Using a Clean Diet to Address Chronic Illness", Fitness Confidential with Vinnie Tortorich

Vinnie was kind enough to have me back on his show.

"On this Friday show, Tucker Goodrich joins Vinnie to talk his health issues, how he is using a clean diet to address so many of them, helping your family members, diet lies, and more."

We talked about how important motivation is for success, as I learned with my father who died last September. Vinnie discussed how he was able to help his parents. 

A tough discussion, on a topic I haven't really gotten into before.

Vinnie's got a number of projects going, including a movie he released (links at his site).

I reviewed his book a couple of years ago, that is here:

"Review: "Fitness Confidential" by Vinnie Tortorich"

H7N9 Influenza Vaccine Trial: Being a Guinea Pig for Science

So I came across a COVID-19 Vaccine Trial:

"Velocity Clinical Research... is looking for healthy participants that have a passion for research and a dedication to help fight COVID. We have a phase 1 COVID-19 vaccine trial... This vaccine is created using a plant based approach."

That was interesting, so I signed up. The ad I saw didn't mention the age range, which was 18 to 49, so, being 53, I didn't qualify.

As a consolation prize, the fellow who contacted me said they were doing a trial on a bird flu vaccine, for which I qualified.

OK, so I signed up for that one instead.

Probably a good thing that I wasn't getting a "plant based" COVID-19 vaccine, whatever the heck that means!

"All adjuvanted vaccines met regulatory acceptance criteria. In groups receiving adjuvanted formulations, seroconversion rates were ≥85.7%, seroprotection rates ≥91.1%, and geometric mean titers ≥92.9% versus 23.2%, 28.6%, and 17.2 for the nonadjuvanted vaccine. The AS03 adjuvant enhanced immune response at antigen-sparing doses. Injection site pain occurred more frequently with adjuvanted vaccines (in ≤98.3% of vaccinees) than with the nonadjuvanted vaccine (40.7%) or placebo (20.0%). None of the 20 serious adverse events reported were related to vaccination."

Well, I'm not suicidal, or a masochist, so this looked reasonable to see from the inside what a vaccine trial looks like.

This is a seriously dangerous virus, compared to SARS-CoV-2.  It's far less contagious, so far, but far more lethal, with a case fatality rate in the 40% range. Yikes! Up until 2020, this was considered one of the prime candidates for a serious pandemic virus, which is why they are developing a vaccine for it.

The trial I seem to be in is this one:

"A Study to Evaluate the Safety and Immunogenicity of GlaxoSmithKline Biologicals' Influenza Vaccine GSK3206641A Administered in Adults 18 to 64 Years of Age and 65 Years of Age and Older."

I say "seem" because at the time I went to the office and found out the details (April 7), this study was listed as "not recruiting", which surprised the physician who saw me, as she said it had been recruiting for a while. It was updated yesterday, however, and now says it is recruiting guinea pigs. Typical bureaucratic SNAFU, in other words. The information that Velocity provided to me suggested going to the clinicaltrials.gov site to look up the details, but didn't provide any information by which one could identify the trial. However this is the only one listed for H7N9. Sigh. 

At any rate, they were all quite surprised that I had actually looked up the trial, and had read the results of the previous trial, and was fully briefed on what was going on. I guess no one does this.

Dry hole.
So I went to the office on the 7th and went through the process. 

  1. Fill out the paperwork, including a medical history, read the disclaimer information and then go through the process of them making sure I'm actually willing to be a guinea pig.
  2. Answer some further questions about my medical history, and get a basic physical. I'm apparently quite healthy, and, most importantly, have no auto-immune diseases, and am not on any immune-suppressing drugs, which I gather would have been disqualifying. Allergies and asthma don't count.
  3. Get a blood draw. Took three tries to get a good draw, but I think the first person to try this wasn't too good at it, the second person had no problem.
  4. Get the vaccine. There are 7 arms to this trial, and only one is the placebo, so it's an 86% chance (6 in 7) that I got something injected.
  5. Go sit in the observation room to see if I grow a third arm or something.
Much to my surprise, I did have a little bit of a reaction to the shot. They injected the vaccine (86% likely) into my right deltoid (shoulder) muscle, and shortly thereafter, I got a mild shooting pain lower down in my arm. I got a few more joint pains around my body, but most noticeable, I got pretty spacey. Not dizzy, but spaced out.

So the physician came out and chatted with me for a few minutes, and decided I was well enough, and sent me on my way. I stopped by a store, and forgot my phone number. Whoops!

But I was well enough. Got a tiny bit of a headache too, but that went away quickly enough.

Running cures what ails you!
Went for a run in the afternoon, and was fine after that.

The joint pains and headache are expected reactions to the injection, btw, so no worries so far.

So now I have to keep a diary each day, and take my temperature—they gave me a digital thermometer for this, which is good, because I don't know where mine is.

Oddly, my temperature has been just above 99F, including before they gave me the shot. 100.4F was their cutoff for a fever, so that didn't disqualify me.

No reaction at the injection site, it's just a tiny bit sore if I press on it, which is typical for any vaccination, but not nearly so bad as a tetanus shot, for instance.

No reactions at all after the first day.

Study protocol. They skipped the pregnancy test.
I have to keep the diary for seven days, then go back for a second shot in a couple of weeks, then follow up by phone to see if I'm still alive for several months after that. The whole trial lasts 13 months.

Oh, they do pay a nominal amount for participating in the trial, and they will cover your medical expenses if you get sick from the shot.

This also means that I am not allowed to get a COVID-19 vaccination for a couple of months, as that would ruin this experiment.

Since I was already either infected or exposed to COVID, I'm not worried about that, especially since the risk to me of being seriously ill with COVID is minute.

Amusingly, they gave me a COVID-19 surveillance form, to see if I come down with COVID-19.

"But the symptoms are the same as the flu", I observed.

"Yes, we know."

So I'll find out in 13 months what they did to me.

P.S. Follow-up 1.

Friday, April 2, 2021

What Causes Heart Disease, LDL or Seed Oils?

Hat tip to Dave Feldman for calling my attention to this podcast: Which sounded interesting, so I downloaded it to listen to on my morning run.

Given the comment by the interviewer, I had been hoping to get farther than a few minutes into my run before having to stop and tweet!

So to be correct, what he says (LDL is the "genetic", "primary cause" of CVD) is what got me. This can only be said by relying on a subset of the science, not, as the interviewer says, "the science".

But let's let Professor Packard put it in his own words (all transcriptions are mine, as are any errors therein. These are all taken from the tweet thread starting with my retweet above.).

He's discussing LDL, and a sub-type of LDL, Lp(a), which is a sub-type of oxidized LDL (oxLDL). He mentions that Lp(a) can be reduced by niacin (nicotinic acid), but that:

"...was put aside because of the THRIVE trial..." 

Huh, so what's the THRIVE trial?

"...participants who were assigned to extended-release niacin–laropiprant had an LDL cholesterol level that was an average of 10 mg per deciliter (0.25 mmol per liter as measured in the central laboratory) lower..."

So if you think LDL causes CVD, then a reduction of LDL must be a good thing, right? Unfortunately, the THRIVE trial was a "failed" trial, one which failed to show a benefit:

"...Among participants with atherosclerotic vascular disease, the addition of extended-release niacin–laropiprant to statin-based LDL cholesterol–lowering therapy did not significantly reduce the risk of major vascular events..."
So LDL is a "genetic" "primary cause" except when it has no effect whatsoever, apparently.

"Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients"

Niacin also reduced Lp(a), among other seemingly beneficial things, "...lowering triglyceride and lipoprotein(a) levels and blood pressure." But all was for naught.

It's an odd cause, in my simple engineering view, that is only occasionally causal, as this is not the first time that reducing LDL has failed to show a benefit for CVD.

Next we come to this:
"...the classic exception is the guy in the [NEJM] who ate 40 eggs a day... and never got any problems with his LDL cholesterol... "
Seriously? We're back to eggs causing heart disease? This is the expert? This was considered debunked in the 1950s, for heaven's sake.
Even the Dietary Guidelines dropped the recommendation against dietary cholesterol for lack of evidence.

"Normal Plasma Cholesterol in an 88-Year-Old Man Who Eats 25 Eggs a Day"

So ponder this: 
"LDL cholesterol is a marker of nutrition. So, that if you have a very poor diet, or you have existing disease, then you'll have a low LDL cholesterol."

Well, I agree with Prof. Packard! In fact, one of my major arguments for avoiding seed oils is the fact that they lower cholesterol, which seems to correlate with their negative effects on heart disease. 

So one would logically conclude a diet change that raised LDL would be good, and one that lowered it (like seed oils) would be bad, right?

He continues: 

"With the canakinumab trial we had a proof of concept, and absolutely correct that Paul [Ridker]... showed that lowering inflammation gave rise to a benefit [in CVD] without a reduction in LDL. And that does suggest that if you target the correct pathway, the correct inflammatory pathway, which is the IL-1β / IL-6 pathway... you end up probably stopping LDL having it's deleterious effects."
We won't get too into the details there, suffice to say that drug stops a cytokine from being produced, and this has a benefit for CVD that does not depend on LDL reduction. 

Now how could we do that to prevent people from getting CVD in the first place?

"The induction of [IL-1β] release from human monocyte-derived macrophages by 9-HODE and cholesteryl-9-HODE suggests a role for modified LDL, and its associated [linoleic acid] oxidation products, in vascular smooth muscle cell proliferation."

That's from 1992, which is shortly after it was shown that LDL alone did not induce the first step of atherosclerosis, it had to be "modified". The modification, it turned out, was the inclusion of linoleic acid from dietary seed oils, which would then become oxidized, and thus pathological, inducing the first step of atherosclerosis—and the rest, IMHO, and as suggested by the canakinumab trial.

"Induction of interleukin 1 beta expression from human peripheral blood monocyte-derived macrophages by 9-hydroxyoctadecadienoic acid."

So after assuring us that LDL is causal, Prof. Packard goes on to demonstrate, from the science, that it is not.

Yes, stop eating the precursor that causes that harmful inflammation, linoleic acid. 

Fix your poor diet: eat no seed oils

Don't worry about LDL.

Here's that podcast.

Listen to Prof. Packard explain (unwittingly) how a low seed oil diet could allow you to stop worrying about your LDL.



Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients. (2014). New England Journal of Medicine, 371(3), 203–212. https://doi.org/10.1056/NEJMoa1300955
Kern, F. (1991). Normal Plasma Cholesterol in an 88-Year-Old Man Who Eats 25 Eggs a Day. New England Journal of Medicine, 324(13), 896–899. https://doi.org/10.1056/NEJM199103283241306
Ku, G., Thomas, C. E., Akeson, A. L., & Jackson, R. L. (1992). Induction of interleukin 1 beta expression from human peripheral blood monocyte-derived macrophages by 9-hydroxyoctadecadienoic acid. Journal of Biological Chemistry, 267(20), 14183–14188. https://doi.org/10.1016/S0021-9258(19)49695-6
Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., Kastelein, J. J. P., Cornel, J. H., Pais, P., Pella, D., Genest, J., Cifkova, R., Lorenzatti, A., Forster, T., Kobalava, Z., … Glynn, R. J. (2017). Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease. New England Journal of Medicine, 377(12), 1119–1131. https://doi.org/10.1056/NEJMoa1707914
Witztum, J. L., & Steinberg, D. (1991). Role of oxidized low density lipoprotein in atherogenesis. Journal of Clinical Investigation, 88(6), 1785–1792. https://doi.org/10.1172/JCI115499

Podcast Interview: Seed Oil Madness with Tucker Goodrich! on Boundless Body Radio with Casey Ruff.

Listen here.
A very fun discussion with Casey Ruff of Boundless Body Radio:

"They are SEED OILS, not vegetable oils, and they are TOXIC. Tucker Goodrich is a warrior against this horrible sludge that is destroying people's health. He is a technology expert who designs, runs, and debugs complex systems in high-risk financial environments. When his health failed him, he started investigating in the same way that he TAUGHT HIMSELF how to manage large, complex software systems by looking at the data, and realized that oxidized vegetable oils were ubiquitously everywhere, and needed to be removed. His health has flourished ever since, and he continues to share his message. We are so grateful for Tucker Goodrich and his message, and we are STOKED that he took the time to speak with us today!"
(I tried to embed the player, which didn't work too well! LOL. Follow the link above to listen or subscribe.)

Saturday, March 27, 2021

Podcast Interview: The Dangers of Seed Oils Part II: Tucker Goodrich Returns with David Gornoski

David Gornoski interviewed me again:

"The Dangers of Seed Oils Part II: Tucker Goodrich Returns with David Gornoski"
"Nutritional researcher Tucker Goodrich returns for another conversation with David Gornoski. The two build on their previous conversation on the harmful effects of PUFAs, the kinds of animal fats our bodies can tolerate, the dangers of soybean oils, the reason for cancer rates going up, ancestral diet, and more. What is oxidation? What kinds of seafood can our bodies tolerate? What is the most effective way of losing weight? Listen to the full podcast to find out."

Or Youtube (where you can see what six hours of sun does to my face!):

 

Friday, March 5, 2021

Podcast Interview (A Twofer!): "The Dangers of Omega 6 Seed Oils" and "Soybean Oil Retardation"

David Gornoski interviewed me not once, but twice recently. A first for me, both of these made it to radio! His show appears on WHBO and WFLA in Florida.

The first interview was on February 27, 2021, and the topic was a familiar one:

"The Dangers of Omega 6 Seed Oils"

Introductory, clearly, but hopefully interesting even if you're familiar with the topic.



Or here, for video:

On March 3 David asked me back to discuss a recent paper:
"Dysregulation of Hypothalamic Gene Expression and the Oxytocinergic System by Soybean Oil Diets in Male Mice" (Deol et al, 2020)
Which was brought to my attention to back in December:
We didn't get into some interesting attributes of this study (like what role linoleic acid actually had) because I wanted to draw attention to some of the previous work this group had done (see citations), leading to my all-time favorite industry rag headline:
"Less Obesity", so they know it causes obesity.

That discussion is here:

The article that spurred the discussing was the EU Times lift of an RT International story (last two citations below), unfortunately I didn't have time to deflate some of the more hyperbolic claims from those two articles: I tried to just stick with the science, which does largely support the hyperbole.

I was introduced to David by Chris Knobbe, MD, so thanks for the introduction, Chris!


Deol, P., Evans, J. R., Dhahbi, J., Chellappa, K., Han, D. S., Spindler, S., & Sladek, F. M. (2015). Soybean Oil Is More Obesogenic and Diabetogenic than Coconut Oil and Fructose in Mouse: Potential Role for the Liver. PloS One, 10(7), e0132672–e0132672. https://doi.org/10.1371/journal.pone.0132672
Deol, Poonamjot, Fahrmann, J., Yang, J., Evans, J. R., Rizo, A., Grapov, D., Salemi, M., Wanichthanarak, K., Fiehn, O., Phinney, B., Hammock, B. D., & Sladek, F. M. (2017). Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice. Scientific Reports, 7(1), 1–13. https://doi.org/10.1038/s41598-017-12624-9
Deol, Poonamjot, Kozlova, E., Valdez, M., Ho, C., Yang, E.-W., Richardson, H., Gonzalez, G., Truong, E., Reid, J., Valdez, J., Deans, J. R., Martinez-Lomeli, J., Evans, J. R., Jiang, T., Sladek, F. M., & Curras-Collazo, M. C. (2020). Dysregulation of Hypothalamic Gene Expression and the Oxytocinergic System by Soybean Oil Diets in Male Mice. Endocrinology. https://doi.org/10.1210/endocr/bqz044
GMO-Sourced Soybean Oil Causes Less Obesity than Conventional Oil. (2017, October 2). GEN - Genetic Engineering and Biotechnology News. https://www.genengnews.com/news/gmo-sourced-soybean-oil-causes-less-obesity-than-conventional-oil/
Soybean Oil Causes Mental Retardation, Autism, Dementia and Alzheimer’s Research Finds. (2020, January 24). [News]. The European Union Times - World News, Breaking News. https://www.eutimes.net/2020/01/soybean-oil-causes-mental-retardation-autism-dementia-and-alzheimers-research-finds/
Would you like brain damage with that? America’s favorite cooking oil causes neurological changes, says animal study. (n.d.). RT International. Retrieved March 3, 2021, from https://www.rt.com/news/479111-soybean-oil-change-mice-brain/

Sunday, February 21, 2021

Seed Oils (Linoleic Acid) and Susceptibility to Burning

This is one of my favorite twitter threads, but twitter is a strange, fluid place, so I thought I would memorialize it here for posterity.

I present the thread first as a narrative; the links to the tweets will appear below, along with the author's information.
Ok, time for a MIND. BLOWN. thread

I was cooking myself lunch just now. I wanted something quick and practical (and meat is always on the menu) so I went for steak and butter on steel pan. About a pound of it.

I'm not a frequent cook so sometimes I mess things up a little.

I was putting away things in the fridge when realized butter was smoking a lot.

I rushed to add the meat, butter splashed and half my thumb got licked by smoking butter (almost 200 C or 350 F)

I had read about @TuckerGoodrich's stories about resistance to sun burn and fire burns when you substitute PUFAs from your diet and my first reaction was confusion:

I very well know what an oil burn feels like and it just didn't hurt as much! Plus, my skin is not even red!

No pain, no redness, no swelling, NADA!

I had already noticed a huge, HUGE difference with my tolerance to sun but this is even crazier!

I'M REALLY IMPRESSED BY THIS!

Of course other factors can't be excluded, such as placebo effect 
😉🙄😂

It's going to take a very, very good reason for me to ever use industrial PUFA oils in my kitchen again.

Funny thing is it's a bit awkward to even talk to people about this. People will surely think I'm crazy (or a quack)....

I'm telling you guys, @TuckerGoodrich is right on to something huge with potencially deep implications for health in general.

Someone has to give this a shot in formal research.

Great stuff. Exciting times

All thanks to Twitter. I would never have known about this anywhere else in a hundred times.

Plus people who are willing to direct you towards links, references and awesome discussions.

Fire-resistance, by diet!

I'm really blown away! Say what you will, quack or not.

End of thread.

Please somehow try this (SAFELY) at home!

Here's his twitter profile:

Guilherme Marquezine

And below are the tweets. Pretty cool.


Wednesday, February 17, 2021

Podcast Interview: "A Cautionary, Fascinating Tale of How So-called 'Heart Healthy' Seed Oils Can Make Us Sick" with Susan Flory.

Susan Flory
Susan Flory

A really nice interview with Susan Flory, whose "The Big Middle" podcast is about "Free-range conversations about living healthier for longer and demanding more from the bigger middle of life"

A cautionary, fascinating tale of how so-called 'heart healthy' seed oils can make us sick

On this episode of The Big Middle, the compelling case against seed and vegetable oils still being touted as ‘heart-healthy’. Those bottles of chemically-extracted fat that take up entire aisles of grocery stores are increasingly seen as hazardous to our health – key drivers of autoimmunity, macular degeneration and the modern plague of lifestyle diseases known as metabolic syndrome.

Even the major makers of soybean, sunflower, corn and other seed and vegetable oils are quietly backing away from them, well aware of the biological damage they can do.

Tucker Goodrich has been sounding the alarm over the health risks of seed oils for more than a decade. He suffered 20 years of gastrointestinal torment and much – scary – more that mystified his doctors. So he dug into the medical science himself, eventually pinpointing industrial seed oils as a villain in his sickness puzzle.

Tucker’s become a recognised world authority on the subject and I guarantee his Patient Heal Thyself story will blow your mind...

The podcast is here, with the usual subscription options, or listen below.



Also, we discuss this: Stephan Guyenet's "Malocclusion: Disease of Civilization" Series, if you want more information.

Stephan Guyenet's "Malocclusion: Disease of Civilization" Series.

 When Justin Owings posted a link to one of the posts in Stephan Guyenet's series*, he couldn't possibly have imagined the effect it would have on my life.

As someone who had stopped eating sugar in hopes it would have a beneficial effect on cavities (it did) I was primed for the message of this series, but I couldn't have imagined the effect it would ultimately have on me.

Since I mention it regularly, I thought I would provide links to the entire series, as it's been someone buried in the mists of time in the internet (it's from 2009!).

Enjoy!

  1. "Malocclusion: Disease of Civilization"
    "In his epic work Nutrition and Physical Degeneration, Dr. Weston Price documented the abnormal dental development and susceptibility to tooth decay that accompanied the adoption of modern foods in a number of different cultures throughout the world. Although he quantified changes in cavity prevalence (sometimes finding increases as large as 1,000-fold), all we have are Price's anecdotes describing the crooked teeth, narrow arches and "dished" faces these cultures developed as they modernized.

    "Price published the first edition of his book in 1939. Fortunately, 
    Nutrition and Physical Degeneration wasn't the last word on the matter. Anthropologists and archaeologists have been extending Price's findings throughout the 20th century. My favorite is Dr. Robert S. Corruccini, currently a professor of anthropology at Southern Illinois University. He published a landmark paper in 1984 titled "An Epidemiologic Transition in Dental Occlusion in World Populations" that will be our starting point for a discussion of how diet and lifestyle factors affect the development of the teeth, skull and jaw (Am J. Orthod. 86(5):419)*....

    "...Over the course of the next several posts, I'll give an overview of the extensive literature showing that hunter-gatherers past and present have excellent occlusion, subsistence agriculturalists generally have good occlusion, and the adoption of modern foodways directly causes the crooked teeth, narrow arches and/or crowded third molars (wisdom teeth) that affect the majority of people in industrialized nations. I believe this process also affects the development of the rest of the skull, including the face and sinuses.

  2. "Malocclusion: Disease of Civilization, Part II"

  3. "Malocclusion: Disease of Civilization, Part III"

  4. "Malocclusion: Disease of Civilization, Part IV"

  5. "Malocclusion: Disease of Civilization, Part V"

  6. "Malocclusion: Disease of Civilization, Part VI"

  7. "Malocclusion: Disease of Civilization, Part VII"

  8. "Malocclusion: Disease of Civilization, Part VIII"

  9. "Malocclusion: Disease of Civilization, Part IX"

    "A Summary

    "For those who didn't want to wade through the entire nerd safari, I offer a simple summary.

    "Our ancestors had straight teeth, and their wisdom teeth came in without any problem. The same continues to be true of a few non-industrial cultures today, but it's becoming rare. Wild animals also rarely suffer from orthodontic problems.

    "Today, the majority of people in the US and other affluent nations have some type of malocclusion, whether it's crooked teeth, overbite, open bite or a number of other possibilities...."

    Two identical twins, the only difference is in dental treatment. From post IX.




* Whole Health Source was Stephan's original site, which he's (mostly) left up as it was. All these articles were posted there. His new site is here.

Saturday, February 6, 2021

Podcast Interview: "Dr. Cate Shanahan & Tucker Goodrich on the True Cause of Disease and How We Know This" with Brian Sanders


Excellent discussion with Dr. Cate Shanahan and Brian Sanders. Very fun!
"Today is a special show that I really enjoyed with 2 guests - Dr. Cate Shanahan and Tucker Goodrich. I had Tucker on years ago for episode 20 and he laid out the entire case against seed oils which was very compelling. Dr. Cate has been on twice already (more recently) and is a wealth of knowledge on many, many things, especially the dangers of seed oils and reinforcing the Sapien diet concepts. We cover how people get fat & sick all the way down to the mitochondrial level. We discuss the different players in this process including seed oils (or more specifically excess amounts of omega-6), refined grains, and sugar.

"We also do my favorite thing and look at all sides of the arguments. We use an article a seed oil supporter wrote as a tool to check in on the studies and claims cited. You won’t want to miss this one! It’s a long one, but we cover a lot, and there’s a bunch of great new info....
Follow the link above for the whole thing.

Sunday, January 24, 2021

Comments

 After marveling that almost no-one ever comments on my blog, I've just noticed that there are loads "pending moderation".

Not quite sure what is going on, as I've not been receiving notifications for these, but I'll go through them.

Of course some junk spam comments have gotten through.

Typical Google software.

Thursday, January 21, 2021

Interesting Study: "Effect of a Plant-Based, Low-Fat Diet versus an Animal-Based, Ketogenic Diet on Ad Libitum Energy Intake"

This is from Kevin Hall, who's a very polarizing figure in the LCHF/Keto diet community, and will be even more so after this!
"The carbohydrate–insulin model of obesity posits that high-carbohydrate diets lead to excess insulin secretion, thereby promoting fat accumulation and increasing energy intake. Thus, low-carbohydrate diets are predicted to reduce ad libitum energy intake as compared to low-fat, high-carbohydrate diets....
"The primary outcomes compared mean daily ad libitum energy intake between each 2-week diet period as well as between the final week of each diet. We found that the low-fat diet led to 689 ± 73 kcal d−1 less energy intake than the low-carbohydrate diet over 2 weeks (P < 0.0001) and 544 ± 68 kcal d−1 less over the final week (P < 0.0001). Therefore, the predictions of the carbohydrate–insulin model were inconsistent with our observations."

"Figure 3. Body weight and composition changes.
A) Both the ABLC and PBLF diets led to progressive
weight loss over time with the ABLC diet resulting
in more rapid weight loss during the first week.
B) Fat-free mass decreased significantly
only during the ABLC and accounted for the majority
of the observed weight loss. C) Body fat mass decreased
with the PBLF diet but was not significantly
decreased with the ABLC diet."
The Keto diet people lost more weight, but it was "fat-free" weight, which in this case means water. (ABLC = Animal-Based, Low Carbohydrate; PBLF = Plant-Based, Low-Fat.)

"Despite the substantial differences in energy intake between the PBLF and ABLC diets, total weight loss after two weeks was surprisingly similar. Greater weight loss during the first week of the ABLC diet as compared to the PBLF diet was likely due to differences in body water, glycogen, and gastrointestinal contents. Indeed, fat-free mass was decreased significantly with the ABLC diet whereas fat-free mass was relatively preserved with the PBLF diet."

Surprisingly, "Only the PBLF diet led to a significant body fat loss."

So the keto diet "won", but not in a meaningful way, as the knock on the LCHF diet has long been that the weight loss was water loss, and not really fat loss—which is of course what you want!

I have personally been on an intermittent keto diet for going on 10 years now. I can assure you that the initial weight loss was not water loss, as I've managed to maintain it for these 10 years. I've coached people who've seen significant weight loss, in one case 56 pounds over 10 weeks, which has so far also stayed off.

So these results don't reflect my experience.

But Hall structured this as a test of what's known as the Carbohydrate/Insulin Model of obesity, in other words that carbohydrate causes a rise in insulin, which causes fat accumulation. The CIM took a bit of a beating here, as indeed they had higher insulin, but they also ate less, without feeling hungry, and lost more fat.

I think that a ketogenic diet is the most efficient way to lose weight, but I don't think that our obesity epidemic is the result of eating carbohydrates. My hypothesis is that it's omega-6 fats that are the culprit.

Well, luckily the "underperforming" keto diet in this study was not one that I eat myself, or that I would recommend someone else eat. 


This study really wasn't testing this hypothesis, but it happens that the seemingly underperforming ABLC diet was 15% (by energy) n-6 PUFA, while the PBLF diet was less than 3%. The reigning animal model for inducing obesity used 8% energy as n-6 PUFA (more about that in a future post).

So while a lot of LCHF advocates who think it's carbohydrate that is driving the obesity epidemic are a bit disgruntled with this paper, I'm happy to see that Hall didn't gore my ox!

Yet.




NB: I was working off a pre-print version of this paper. I may have to revise this post if it winds up that the published version is wildly different.

Goodrich, T. (2017, November 9). Omega-6 Fats: The Alternative Hypothesis for Chronic Disease. Yelling Stop. http://yelling-stop.blogspot.com/2017/11/omega-6-fats-alternative-hypothesis-for.html
Hall, K. D., Guo, J., Courville, A. B., Boring, J., Brychta, R., Chen, K. Y., Darcey, V., Forde, C. G., Gharib, A. M., Gallagher, I., Howard, R., Joseph, P. V., Milley, L., Ouwerkerk, R., Raisinger, K., Rozga, I., Schick, A., Stagliano, M., Torres, S., … Chung, S. T. (2021). Effect of a plant-based, low-fat diet versus an animal-based, ketogenic diet on ad libitum energy intake. Nature Medicine, 1–10. https://doi.org/10.1038/s41591-020-01209-1