How Seed Oils Make You Fat, with Tucker Goodrich and Jeff Nobbs—Fundamental Health with Dr. Paul Saladino

Another terrific discussion with Paul Saladino. 

"Today, Paul interviews Tucker Goodrich, Wall Street technology [exec] extraordinaire and independent researcher, and Jeff Nobbs, co-founder and CEO of Zero Acre Farms. They take a deep dive into the epidemic of seed oil consumption. They examine conflicting arguments, and then explain why seed oils are likely making humans fat, diabetic, and causing atherosclerosis."

Embedded video:

Podcast:

We discuss these two posts on Zero Acre's website:

"How Vegetable Oils Make Us Fat"

"Seed Oils as a Driver of Heart Disease"

Jeff has retained me as a paid consultant to Zero Acre to help him and his team develop content like this to spread the news about the health issues with industrial seed oils. As such, I thought it was important, when Paul reached out to me initially, to include Jeff. 

He's the real deal, he's doing this because he understands it and believes in it, and he and the Zero Acre team want to make sure we get the science right.

It's an excellent discussion, I think. Enjoy!

Interview: "Ending the Debate Over Seed Oils"—Fundamental Health with Paul Saladino

This is from August 23rd of last year, but I just realized that I forgot to post about it. It's a follow-up to this:

New Interview: "Fundamental Health with Paul Saladino, MD: How Seed Oils Destroy Your Mitochondria and Lead To Chronic Disease

A bunch of people on Twitter had commented on what a great interview the above was, and I agree, so I reached out to Paul about doing a follow-up.

Enjoy!

Paul has a lot of good material and interviews, so do consider subscribing to his podcast. I have.

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Paul's notes on this podcast:

Time Stamps:

0:10:16 Podcast begins

0:12:16 Tucker’s blog post: https://yelling-stop.blogspot.com/2021/06/thoughts-on-of-rats-and-sidney-diet.html

0:14:16 Compounds that reduce overeating

0:17:16 Dietary Linoleic Acid Elevates Endogenous 2-AG and Anandamide and Induces Obesity: https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2012.38

0:23:31 Endocannabinoid signal in the gut controls dietary fat intake: https://www.pnas.org/content/108/31/12904

0:29:56 A Neural Circuit for Gut-Induced Reward: https://www.cell.com/cell/fulltext/S0092-8674(18)31110-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867418311103%3Fshowall%3Dtrue

0:35:46 CRP is a marker of oxidized linoleic acid

0:38:32 Dietary linoleic acid intake and blood inflammatory markers: a systematic review and meta-analysis of randomized controlled trials: https://pubs.rsc.org/en/content/articlelanding/2017/FO/C7FO00433H

0:43:06 Take a pill or just stop eating so many seed oils?

0:45:16 Low‐Density Lipoprotein Cholesterol Corrected for Lipoprotein(a) Cholesterol, Risk Thresholds, and Cardiovascular Events: https://www.ahajournals.org/doi/10.1161/JAHA.119.016318

0:49:46 A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans: https://pubmed.ncbi.nlm.nih.gov/9844997/

0:54:16 HNE – what is it and why is it important?

0:58:36 Where is linoleic acid even found?

1:02:46 The average amount of linoleic acid in the human diet

1:12:06 Why I don’t eat bacon

1:14:46 Just because a study was conducted a long time ago, doesn’t mean it should be ruled out

1:20:31 Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73): https://www.bmj.com/content/353/bmj.i1246

1:27:16 When low LDL can result in a higher risk of cardiovascular disease

1:28:31 Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis: https://www.bmj.com/content/346/bmj.e8707

1:32:16 Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study: https://pubmed.ncbi.nlm.nih.gov/9989963/

1:40:40 The blood test you should consider getting

1:42:55 The idea of “Intralipid”

1:51:00 Tucker’s personal experience with weight loss and dietary changes

2:03:10 Health Characteristics of the Wayuu Indigenous People: https://academic.oup.com/milmed/article/184/7-8/e371/5481850

New Interview: "Fundamental Health with Paul Saladino, MD: How Seed Oils Destroy Your Mitochondria and Lead To Chronic Disease, with Tucker Goodrich"

This was a very fun interview, and it was sort of a follow-up to an interview Paul Saladino did with Petro (Peter) Dobromylskyj of Hyperlipid a little while back.

We discuss the effect excess linoleic acid has on the mitochondria and the electron transport chain, and what effects some of the metabolites of linoleic acid produced during mitochondrial breakdown have on the body and chronic, "Western" diseases.

Here is Paul's site with notes on what we're talking about with some references, and my outline/notes for the podcast: 

Linoleic Acid and Its Metabolites, a Primer

With a ridiculous number of references, including links to a bunch of other posts of mine that this builds upon (see below).

And here's the interview he did with Peter , which we discuss several times:

And Paul's notes on that interview.

Enjoy!

Paul has a lot of good material and interviews, so do consider subscribing to his podcast. I have.

P.S. We did a follow-up, published 8/23/2021:

Interview: Ending the Debate Over Seed Oils—Fundamental Health with Paul Saladino

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Selective bibliography for this podcast, referencing my other posts.

Goodrich, T. (2016a, February 5). The Cause of Metabolic Syndrome: Excess Omega-6 Fats (Linoleic Acid) in Your Mitochondria. Yelling Stop. http://yelling-stop.blogspot.com/2016/02/the-cause-of-metabolic-syndrome-excess.html

Goodrich, T. (2016b, February 23). How To Prevent Oxidative Damage In Your Mitochondria. Yelling Stop. http://yelling-stop.blogspot.com/2016/02/how-to-prevent-oxidative-damage-in-your.html

Goodrich, T. (2016c, February 24). What Effect Does Linoleic Acid Have On Mitochondria? Yelling Stop. http://yelling-stop.blogspot.com/2016/02/what-effect-does-linoleic-acid-have-on.html

Goodrich, T. (2018, June 28). What’s Worse—Carbs or Seed Oils? Understanding a High-PUFA Diet. Yelling Stop. http://yelling-stop.blogspot.com/2018/06/whats-worsecarbs-or-seed-oils.html

Goodrich, T. (2020, June 2). Does Consumption of Omega-6 Seed Oils Worsen ARDS and COVID-19? [Blog]. Yelling Stop. http://yelling-stop.blogspot.com/2020/06/does-consumption-of-omega-6-seed-oils.html