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| Dr. Anthony Gustin's Natural State Podcast |
Here is part 2 of this interview:
"The Science Behind Vegetable Oils and Why They’re Terrible For You"—The Natural State with Dr. Anthony Gustin
In this continuation of the interview, we:
...Dive deeper into the science to see what the research shows when it comes to vegetable oils and inflammation, cholesterol, chronic diseases, and more....
Here’s a look at some of the overarching topics we cover in this episode:
- Does consuming seed oils really lead to increased inflammation?
- What trials on linoleic acid consumption and migraines showed
- Aren’t seed oils better for your cholesterol?
- What the Lyon Diet Heart study discovered as the most successful heart disease prevention strategy
- How are seed oils connected to heart disease?
- What forced the US to ban trans fats and is there any chance it can happen with seed oils next?
- Is linoleic acid essential if it’s found naturally in foods?
- How Tucker thinks we should approach seed oils
- How seed oils sneak into the meat you’re eating
- What Dr. Cate Shanahan believes we could have done differently with the Covid-19 pandemic and Tucker’s thoughts on this
(From Anthony's show notes.)
NB: We are both advisors/consultants to Zero Acre Farms.
In the Podcast It was noted that nobody is eating a low level of linoleic acid. So, arachidonic acid levels are typically at the top end of possible values.
ReplyDeleteThat's a valid observation when the background diet contains very little, if any, arachidonic acid. Most times, that is not the case.
In a 2019 paper entitled “A systematic review of the effects of increasing arachidonic acid intake on PUFA status, metabolism and health-related outcomes in humans”, Philip Calder concluded that "an increase in arachidonic acid intake up to 1.5 grams per day does not significantly change the parameters associated with inflammation"[1]. However, in a 2007 article entitled “Dietary arachidonic acid: harmful, harmless or helpful?” Calder remarked, “Nevertheless, it is important to keep in mind that, just because there is little biological impact of an increase in arachidonic acid intake or status, there may still be significant benefit from a decrease in its intake or status[2].”
Apparently, there is little interest in performing experiments wherein a decrease in arachidonic acid intake is part of the protocol. Perhaps that’s why the Physicians Committee for Responsible Medicine and others are obliged to cite a 2003 paper by Olaf Adam [3] when they publish commentary about the benefits of plant-based diets for relieving arthritis symptoms.[4]
Interestingly, in 2019 a former student of Olaf Adam, Johan Woelber, reduced arachidonic and linoleic acid intake by swapping animal protein for plant protein in a gingivitis study. It was reported that at the end of the 12-week trial that subjects in the experimental arm experienced significant weight loss[5].
In FADS2 rs174575 gene polymorphism research published in 2020 it was concluded that
“Reduced PUFA levels, mainly omega 3 FAs, increased LA (from dietary major sources, such as seed oils), and AA (Arachidonic acid) accumulation activates NF-Kappa B, transcribing COX (Cyclooxygenase) and lipo-oxygenase genes and increasing inflammation. This reduces insulin sensitivity and increases insulin resistance[6].”
In 2022 researchers in India concluded that “From the obtained results it is confirmed that there exists a functional link between fatty acid desaturase gene polymorphism and lipid profile status in type-2 diabetes mellitus[7].
As far back as 2005 researchers in Sweden noted that "Genetic variants in FADS1/FADS2 are known to correlate with the variability of LC-PUFAs levels in serum/plasma, erythrocyte membranes and adipocytes, and are associated with inflammation, cardiovascular disease and type 2 diabetes[8]."
Ironically, excessive intake of linoleic acid in conjunction with a vegan diet has been shown to dampen the impact of excessive arachidonic acid accumulation[9].
References
1. https://pubmed.ncbi.nlm.nih.gov/31130146/
2. https://pubmed.ncbi.nlm.nih.gov/17705889/
3. https://link.springer.com/article/10.1007/s00296-002-0234-7
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359818/
5. https://onlinelibrary.wiley.com/doi/10.1111/jcpe.13094
6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351823/
7. https://www.nature.com/articles/s41598-021-92572-7
8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124650/
9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472059/