Interview: "How Seed Oils Oxidise Cardiolipin and Damage Your Mitochondria" with Max Gulane MD on the Regenerative Health Podcast

Max is an emergency room physician who has an interest in what underlies our chronic disease pandemic.

We spoke once before (below) and Max had some follow-up questions, which led to this interesting discussion.

In going through it to to put together the show notes, I found myself thinking that I sounded like Ray Peat, with a dense, frankly difficult-to-follow narrative style.

Yes, it's all backed by solid evidence, but it can be tough to follow, and as I commented to Max after it was finished, getting all the references was going to be a chore. It was, and I didn't attempt to track them all down.

So if you have questions, post them below.

RHP #30: "How seed oils oxidise cardiolipin and damage your mitochondriaHow seed oils oxidise cardiolipin and damage your mitochondria"

"Tucker Goodrich and I explore sub-cellular mechanisms by which seed oils are damaging your health. We cover mitochondrial bio-energetic aetiology of disease, linoleic acid and oxidation of mitochondrial cardiolipin, how seed oils contribute to visceral fat, Tucker’s opinion on Dr Jack Kruse’s work and much, much more. 

 

"This is quite a technical discussion with emphasis on the exact mechanisms of see oil harm. If you’re just learning about how seed oils damage health, I suggest listening to my first podcast with Tucker (RHP #12) for an introduction.

 

"Tucker is a financial risk analyst, self-taught engineer and citizen scientist who is a world expert in the the biochemistry of seed oils and their impact on human health.

RHP #12: "Toxic harm of seed oils, linoleic acid and lipid peroxidation products"

"Tucker Goodrich joins me to discuss seed oils, linoleic acid, 4-HNE, toxic breakdown products of linoleic acid, the evidence implicating seed oils in liver disease, obesity, diabetes, cancer and heart disease and much, much more.

He has a timeline of our discussion at the link above. Scroll down this page for the show notes.

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Show notes on RHP #30

Doug Wallace on Mitochondria (T. Goodrich, 2020a)

Book by doctor with multiple sclerosis (Wahls, 2010)

Famous biologist: " ...The great tragedy of Science—the slaying of a beautiful hypothesis by an ugly fact..."—Thomas Henry Huxley

Mitochondrial ATP synthase image is here (T. Goodrich, 2016a)

Seyfried interview (T. D. Goodrich, 2021)

Danny Lauria on ‘floxxing’ (Gulhane, 2023)

Light emission from auto-oxidizing fats (Miyamoto et al., 2012)

Twin astronauts (Garrett-Bakelman et al., 2019)

Linseed oil is not a solvent. Whoops. Here’s a video on auto-oxidation: https://www.youtube.com/watch?v=9yq6VW-c2Ts

Washing machine warning label: https://twitter.com/TuckerGoodrich/status/1567573638458789890?s=20

Oxidized cardiolipin inducing apoptosis: (Kagan et al., 2005)

“How to Prevent Oxidative Damage In Your Mitochondria” (T. Goodrich, 2016b)

Anti-phospholipid syndrome and oxidized cardiolipin (Tuominen et al., 2006)

Cardiolipin composition (some of the links) (T. Goodrich, 2016a)

Linoleic acid and migraine (Ramsden et al., 2012, 2013, 2018)

HNE and pyruvate dehydrogenase (Humphries & Szweda, 1998; Vadvalkar et al., 2017)

ARDS and Leukotoxin (T. Goodrich, 2020b)

Bruce Hammock interview (Gornoski, 2021)

Bruce Hammock and Leukotoxin in COVID (McReynolds et al., 2021)

Linoleic acid is not an essential fat (Carlson et al., 2019; Le et al., 2012)

Omega-6 metabolite toxicity vs Omega-3 (Stanley et al., 2012)

Died at 102, not 103: Large radiation dose with no ill effects (Taylor et al., 2004)

Radiation and linoleic acid (Horgan et al., 1957)

Avoid animals fed high amounts of seed oils (Midtbø et al., 2013)

Lard is obesogenic when coming from industrially-fed pigs (T. Goodrich, 2011)

Linoleic acid preferentially burned from adipose tissue when fasted (Cunnane et al., 2001)

 

References

 

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Cunnane, S. C., Ross, R., Bannister, J. L., & Jenkins, D. J. (2001). Beta-oxidation of linoleate in obese men undergoing weight loss. The American Journal of Clinical Nutrition, 73(4), 709–714. https://doi.org/10.1093/ajcn/73.4.709

Garrett-Bakelman, F. E., Darshi, M., Green, S. J., Gur, R. C., Lin, L., Macias, B. R., McKenna, M. J., Meydan, C., Mishra, T., Nasrini, J., Piening, B. D., Rizzardi, L. F., Sharma, K., Siamwala, J. H., Taylor, L., Vitaterna, M. H., Afkarian, M., Afshinnekoo, E., Ahadi, S., … Turek, F. W. (2019). The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science, 364(6436), eaau8650. https://doi.org/10.1126/science.aau8650

Goodrich, T. (2011, November 19). Linoleic Acid, Fat Rats in Labs, and Fat Humans. Yelling Stop. http://yelling-stop.blogspot.com/2011/11/linoleic-acid-fat-rats-in-labs-and-fat.html

Goodrich, T. (2016a, February 5). The Cause of Metabolic Syndrome: Excess Omega-6 Fats (Linoleic Acid) in Your Mitochondria. Yelling Stop. http://yelling-stop.blogspot.com/2016/02/the-cause-of-metabolic-syndrome-excess.html

Goodrich, T. (2016b, February 23). How To Prevent Oxidative Damage In Your Mitochondria. Yelling Stop. http://yelling-stop.blogspot.com/2016/02/how-to-prevent-oxidative-damage-in-your.html

Goodrich, T. (2020a, January 8). How Mitochondrial Defects Can Cause Various Seemingly Unrelated Diseases. Yelling Stop. https://yelling-stop.blogspot.com/2020/01/how-mitochondrial-defects-can-cause.html

Goodrich, T. (2020b, June 2). Does Consumption of Omega-6 Seed Oils Worsen ARDS and COVID-19? [Blog]. Yelling Stop. http://yelling-stop.blogspot.com/2020/06/does-consumption-of-omega-6-seed-oils.html

Goodrich, T. D. (2021, July 8). Interview: Thomas Seyfried on Glioblastoma, Metabolic Cancer Breakthroughs, with David Gornoski on A Neighbor’s Choice [Blog]. Yelling Stop. https://yelling-stop.blogspot.com/2021/07/podcast-interview-thomas-seyfried-with.html

Gornoski, D. (2021, May 24). Omega 6 Linoleic Acid Research with Prof. Bruce Hammock, Prof. Bruce German, and Tucker Goodrich (No. 5/24/2021) [Mp3]. https://aneighborschoice.com/omega-6-linoleic-acid-research-with-prof-bruce-hammock-prof-bruce-german-and-tucker-goodrich/

Gulhane, M. (2023, May 23). Danny Lauria: Recovering from “floxxing” with mitochondrial and circadian practices (No. 25) [Mp3]. https://podcasts.apple.com/us/podcast/regenerative-health-with-max-gulhane-md/id1661751206

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Humphries, K. M., & Szweda, L. I. (1998). Selective Inactivation of α-Ketoglutarate Dehydrogenase and Pyruvate Dehydrogenase: Reaction of Lipoic Acid with 4-Hydroxy-2-nonenal. Biochemistry, 37(45), 15835–15841. https://doi.org/10.1021/bi981512h

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Le, H. D., Meisel, J. A., de Meijer, V. E., Fallon, E. M., Gura, K. M., Nose, V., Bistrian, B. R., & Puder, M. (2012). Docosahexaenoic Acid and Arachidonic Acid Prevent Essential Fatty Acid Deficiency and Hepatic Steatosis. Journal of Parenteral and Enteral Nutrition, 36(4), 431–441. https://doi.org/10.1177/0148607111414580

McReynolds, C. B., Cortes-Puch, I., Ravindran, R., Khan, I. H., Hammock, B. G., Shih, P. B., Hammock, B. D., & Yang, J. (2021). Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections. Frontiers in Physiology, 12. https://doi.org/10.3389/fphys.2021.663869

Midtbø, L. K., Ibrahim, M. M., Myrmel, L. S., Aune, U. L., Alvheim, A. R., Liland, N. S., Torstensen, B. E., Rosenlund, G., Liaset, B., Brattelid, T., Kristiansen, K., & Madsen, L. (2013). Intake of farmed Atlantic salmon fed soybean oil increases insulin resistance and hepatic lipid accumulation in mice. PloS One, 8(1), e53094. https://doi.org/10.1371/journal.pone.0053094

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