Somewhat off-topic, but I was just reading the following blog post and marveling at how some people can come to conclusions so opposite to those you and Peter come to: https://fanaticcook.com/2020/11/27/prolonged-exposure-of-our-muscles-to-high-levels-of-fat-leads-to-severe-insulin-resistance-with-saturated-fats-demonstrated-to-be-the-worst/
I suspect some of the divergence in opinions comes from their not distinguishing between short-term insulin resistance (good if it keeps fat out of your adipocytes) and long-term chronic systemic insulin resistance (bad, that's metabolic syndrome).
But the post talks mainly about muscle cells, not adipocytes; I don't know whether different types of fats affect the insulin sensitivity/resistance of muscle cells the way they do adipocytes. Do saturated fats make muscles more insulin resistance? (It might make sense, if the body wants the muscles to burn fat when lipolysis is happening.) Does that in turn cause fat to accumulate in muscles, as the article alleges?
I was also struck by the statement, " Saturated fat causes more of those toxic breakdown products and mitochondrial dysfunction, and increases oxidative stress, free radicals, and inflammation." What toxic breakdown products? More toxic than 4-HNE? Regarding oxidative stress, we know that saturated fats generate more ROS for signaling, but we think that's a good thing. Is it necessarily inflammatory?
Anyway, if you have a chance to read the post and share your thoughts, I'd love to hear them. Are there more misconceptions than the ones I've identified, or are some of the article's points good?
The article appears to be lacking in a basic understanding on human biochemistry. If you eat no fat and only carbs, your body will make saturated fat and then convert about 50% of it to monounsaturated. Most of the saturated fat will be palmitic acid. Insulin resistance evolved to spare glucose for tissues and biochemical processes where is it absolutely necessary, since most of the body is happy to run on fat or derivatives of fat. The bulk of excess calories from carbs is stored as fat. If the body preferred to run on glucose, then animals would have evolved a way to store more glucose, the way plants do.
MR GOODRICH PLEASE write me an email as I don't know how to contact you (linkedin?)
I'd like to talk to you about a book publishing / translation project (German), in which I would use your recent podcasts. I have experience in this field, my latest book was the one by Dr. T. Seyfried, see https://www.amazon.de/s?k=rockermeier+seyfried Have a good day! My email: Jorockermeiergmail.com
Somewhat off-topic, but I was just reading the following blog post and marveling at how some people can come to conclusions so opposite to those you and Peter come to:
ReplyDeletehttps://fanaticcook.com/2020/11/27/prolonged-exposure-of-our-muscles-to-high-levels-of-fat-leads-to-severe-insulin-resistance-with-saturated-fats-demonstrated-to-be-the-worst/
I suspect some of the divergence in opinions comes from their not distinguishing between short-term insulin resistance (good if it keeps fat out of your adipocytes) and long-term chronic systemic insulin resistance (bad, that's metabolic syndrome).
But the post talks mainly about muscle cells, not adipocytes; I don't know whether different types of fats affect the insulin sensitivity/resistance of muscle cells the way they do adipocytes. Do saturated fats make muscles more insulin resistance? (It might make sense, if the body wants the muscles to burn fat when lipolysis is happening.) Does that in turn cause fat to accumulate in muscles, as the article alleges?
I was also struck by the statement, " Saturated fat causes more of those toxic breakdown products and mitochondrial dysfunction, and increases oxidative stress, free radicals, and inflammation." What toxic breakdown products? More toxic than 4-HNE? Regarding oxidative stress, we know that saturated fats generate more ROS for signaling, but we think that's a good thing. Is it necessarily inflammatory?
Anyway, if you have a chance to read the post and share your thoughts, I'd love to hear them. Are there more misconceptions than the ones I've identified, or are some of the article's points good?
The article appears to be lacking in a basic understanding on human biochemistry. If you eat no fat and only carbs, your body will make saturated fat and then convert about 50% of it to monounsaturated. Most of the saturated fat will be palmitic acid. Insulin resistance evolved to spare glucose for tissues and biochemical processes where is it absolutely necessary, since most of the body is happy to run on fat or derivatives of fat. The bulk of excess calories from carbs is stored as fat. If the body preferred to run on glucose, then animals would have evolved a way to store more glucose, the way plants do.
ReplyDeleteMR GOODRICH PLEASE write me an email as I don't know how to contact you (linkedin?)
ReplyDeleteI'd like to talk to you about a book publishing / translation project (German), in which I would use your recent podcasts. I have experience in this field, my latest book was the one by Dr. T. Seyfried, see https://www.amazon.de/s?k=rockermeier+seyfried Have a good day! My email: Jorockermeiergmail.com