Saturday, February 6, 2021

Podcast Interview: "Dr. Cate Shanahan & Tucker Goodrich on the True Cause of Disease and How We Know This" with Brian Sanders

Excellent discussion with Dr. Cate Shanahan and Brian Sanders. Very fun!
"Today is a special show that I really enjoyed with 2 guests - Dr. Cate Shanahan and Tucker Goodrich. I had Tucker on years ago for episode 20 and he laid out the entire case against seed oils which was very compelling. Dr. Cate has been on twice already (more recently) and is a wealth of knowledge on many, many things, especially the dangers of seed oils and reinforcing the Sapien diet concepts. We cover how people get fat & sick all the way down to the mitochondrial level. We discuss the different players in this process including seed oils (or more specifically excess amounts of omega-6), refined grains, and sugar.

"We also do my favorite thing and look at all sides of the arguments. We use an article a seed oil supporter wrote as a tool to check in on the studies and claims cited. You won’t want to miss this one! It’s a long one, but we cover a lot, and there’s a bunch of great new info....
Follow the link above for the whole thing.


  1. G’day Tuck - Great interview! Keep up the good work you’re doing and spreading around.
    ~J.D. Shields

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  3. Tuck, your handling of that vegan is the thing of legend! #BeLikeYouWhenIGrowUp

  4. I got to wondering if anything could inhibit the toxic effects of pufas by reducing oxidation in vivo. I found this paper that shows that the tocotrienol rich fraction of Vit E is quite effective. Perhaps it could be added to cooking oil. It is heat stable but would probably get used up pretty quickly. I'm not sure of the mechanics of free-radical scavenging. Here is the link to the paper :

  5. I was the one who suggested this podcast! I am happy that you guys did it! I'm a big fan of you both! and Brian's too. Cheers from Brazil.

  6. Hi Tucker, in this interview you touched on excess Omega 3's in the diet. I've got somewhat of a detailed question and am hoping you can point me to some literature that might shine a bit more light on this. Some background: I've eaten a low seed oil diet for a decade, paleo style diet for the same amount of time. About two years ago I began to become intolerant to exercise/physical exertion. I have had the damndest time sorting out what is going on. I was an avid tennis player/hiker/crossfitter. But essentially physical exertion causes my heart to race, I get shaky, sleep goes to hell for the next few days, etc. Essentially my nervous system becomes over-trained with just a bit of work. I used to overtrain occassionally with these same symptoms. But that would heal itself with the week off from exercise (after ~8 weeks of work I'd take a week off). Curious if this rings a bell for you or you might have any ideas whether excess Omega 3 consumption could lead to this. I love mackerel and sardines and eat them daily. Recent serum FA's show 14.8% Omega 3, 23.9% Omega 6, 19.5% mono, 41.4% saturated, 0.4% trans. Within that Omega 6 percentage, LA 12.2% and AA 9.1%.

    Thanks and keep up the great work.

    1. I think it's likely a stretch to blame this on n-3 consumption from fish, but it's conceivable (based on DHA replacing LA in the heart mitochondria).

      I presume you got an Omega Quant test? According to this sample report, you're just a bit over the reference range for n-3. Reference ranges in lab reports are generally set based on the population for which the test is used.

      "Full Fatty Acid Profile Report"

      You're a bit over the top of the range stated (14.8 vs 2.92 - 13.29). I don't know if they're including populations with a high n-3 intake in those ranges, or just Americans, but it's likely you're within a normal human range. You might reach out to them to determine the population for the range.

      You could also look at this:

      "Global survey of the omega-3 fatty acids, docosahexaenoic acid and eicosapentaenoic acid in the blood stream of healthy adults"

      And see if you can correlate to your results.

      But probably the easiest thing to do to rule this out would be to eat less fatty fish for a few weeks, and see if you notice an amelioration of the symptoms.

      Good luck!

    2. Test was a True Health assay but presumably outsourced to someone like Omega. Much appreciated. I'll report back if this route is fortuitous.