"We brought together Alan Flanagan and Tucker Goodrich to debate a few topics, mainly the dangers of Poly Unsaturated Fats.
"Alan Flanagan has an MSc in Nutritional Medicine, is currently pursuing his PhD. He is also a former practicing Lawyer (Barrister) from Dublin, Ireland. Alinea Nutrition is his online education hub, dedicated to empowering others with clear, impartial evidence-based knowledge and understanding about the science of nutrition.
"Tucker Goodrich is a technology executive in the financial industry who designs, runs, and debugs complex systems in high-risk environments. Areas of expertise include risk management, systems management, and cyber-security. He is also an Expert Advisor for the nutrition start-up Nutrita, and has been a guest on numerous podcasts.
"Links and info Tucker Referenced in the discussion: http://yelling-stop.blogspot.com/2021/08/show-notes-for-flanagan-and-goodrich-on.html"
Here's a link to the podcast, and here's an embedded player:
Show notes for Flanagan and Goodrich on Mark Bell's Power Project Podcast
The post that started this: Thoughts on 'Of Rats and Sidney Diet Heart...', Alan Flanagan's Post Defending Seed Oils
I haven't listened yet.....but I can say....love LMNT.
ReplyDeleteOK - just need to find a spare couple hours....
ReplyDeleteHi, well organized papers and arguments, Tucker.
ReplyDelete1. Flanagan was referring to Yki-Järvinen study 1:17, which Peter dissects so nicely. http://high-fat-nutrition.blogspot.com/2018/07/butter-gives-you-fatty-liver-again.html
You referred to Swedish muffins "study". Frozen logic in both...
2. Gura and Omegaven. From Europe this intralipid omega-6 poisoning ongoing trial is like not washing your hands from corpses room to babies delivery room. Gura is your "Semmelweiss". This data is priceless, and as you say, it would be unethical to random test it anymore. They turn yellow on Intralipid, and pink again with Omegaven? However, I read Gura's own handed version, and the producer has a fat mix for the IV purpose, they do not use omegaven for total parenteral nutrition. I would like to speculate that Omegaven works in context of long-time poisoning before it is being applied? Of course, TPN has also glucose fed, and it requires insulin (due to incretin effect and intralipid O-6 as a background fat does not induce insulin response?). Why glucose IV anyhow, should be not needed...? Sure this has been studied?
3. Nice and polite discussion, congrats.
JR
Thanks JR.
DeleteYes, overfeeding is a significant confounder, it's not a physiological model if it's voluntary (vs driven by some food component.
TPN guidelines recognize that benefit of n-3 may only be apparent compared to n-6, and may be harmful independently. But less so, so it's still an improvement. I covered that in my COVID19/ARDS post, with links to the papers/studies.
Thanks, I thought it was very productive.
While I sincerely appreciate the admirable angles and numerous valid points Mr. Flanagan's topics revolved around (for instance the concern for those that may or may not have resources to significantly impact their choice of foods and particularly their consumed fats), I do think much of his argument was obliterated by the literature that you so eloquently cited and defended. His concerns are well founded, but that really wasn't the topic at hand. The topic (my take) was the increase of dietary PUFA consumption and if they are contributing to the large increases of modern disease we are seeing (all our metabolic dysfunction friends, T2DM, CVD, Alzheimers, etc). And with this as the base of the discussion, a great segue into those probable mechanistic pathways which was backed up by significant literature on these topics.
ReplyDeleteThis was a great one to listen too. And most definitely, as you said, "I thought it was very productive". Couldn't agree more. Thank you so much for this. Keep up the great work. I will be in the audience!