Show notes for Flanagan and Goodrich on Mark Bell's Power Project Podcast

Here it is.

These are notes for things I referenced in the discussion. I didn't try to represent Alan Flanagan's research.

Mark Bell Power Project Podcast on Twitter and the shows.

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Zoom: Using blurred background

Alan’s article (Flanagan, 2020), Tucker’s rebuttal (Goodrich, 2021a)

“Stan Efferding paired us up…”

“Teachings of Ray Peat…” (Goodrich, 2021b; Peat, 2007)

“Nutritional transition” (Drewnowski & Popkin, 1997)

Rimonabant (Bronander & Bloch, 2007)

2-AG, Obesity (Alvheim et al., 2012; Blüher et al., 2006; Ravinet Trillou et al., 2003)

THC (U.S. National Library of Medicine, 2017; Williams & Kirkham, 2002)

Tsimane heart disease (Kaplan et al., 2017)

Tsimane obesity (Bethancourt et al., 2019)

DGLA & obesity (Hua et al., 2021; Jauregibeitia et al., 2020; Lei et al., 2017; Tsurutani et al., 2018)

Arachidonic acid variation by diet in ‘other tissues’ (Lefkowith et al., 1985)

Brain circuit for obesity (DiPatrizio et al., 2011; Han et al., 2018)

Gastric bypass (Roux-en-Y Gastric Bypass) cuts obesity circuit of endocannabinoid hyperphagia, which regrows (Borg et al., 2006; Guijarro et al., 2008; Meguid et al., 2008; Rubino et al., 2004; Wickremesekera et al., 2005)

Other cause of lung cancer (T. Lee & Gany, 2013)

Asian/African heart attack study (K. T. Lee et al., 1964)

Papers from the 90’s coming out of Japan (Okuyama et al., 1996)

Mediterranean diet: Lyon Diet Heart (de Lorgeril et al., 1994; de Lorgeril et al., 1999)

Pathway to atherosclerosis (Goldstein et al., 1979; Witztum & Steinberg, 1991)

Omega 6 going way up (Blasbalg et al., 2011)

“How many ears of corn you’d have to eat to get a gallon of Wesson corn oil…” (Nobbs, 2020)

“Low fat diets producing worse outcomes…” (Navab Mohamad et al., 2004)

Virta avoid seed oils (S. D. Phinney, 2020)

Phinney acute toxicity mayo (Bourke, 2013; S. D. Phinney et al., 1983; S. Phinney & Volek, 2012)

I need to quote entire section of (S. Phinney & Volek, 2012), as it’s remarkable!

“Back in the day when Steve did his study with the bike racers on the ketogenic diet [(S. D. Phinney et al., 1983)], they had to measure precisely how much of each nutrient his subjects were eating. That limited him to just five menu items from which his subjects could choose each day. Three of these were composed principally of animal fats and two used soybean oil mayonnaise as their fat source. Within a week or two of starting the high fat diet, most of the subjects developed a strong distaste for the mayonnaise-based meals. Opening a new container and then switching brands of mayonnaise didn’t help. Nobody actually got sick eating these tuna salad or chicken salad entrees – they just said that they didn’t feel completely well after eating them.

“Out of curiosity, Steve put himself on a ketogenic diet for a month and fed himself most of his fat intake overnight via a tiny feeding tube in his stomach (so taste wasn’t an issue). Within 3 days of feeding himself 1500 Calories of either soybean or corn oil nightly, he developed quite prominent nausea and gastro-intestinal upset. However when he fed himself the same amount of calories as olive oil for two straight weeks, he had no such symptoms. In between testing these different oils via the feeding tube, Steve maintained nutritional ketosis and met his full calorie needs by eating mostly animal fats, again without symptoms.

“The take-away message from this is that the human system doesn’t seem to tolerate a high fat diet prepared from high omega-6 oils (like soy and corn oils), but does just fine on one consisting mostly of monounsaturated and saturated fats (e.g., olive oil and animal fats). This doesn’t mean you can’t eat mayo, just find one made from olive or canola oil or make your own. And please, don’t be fooled by the agindustry advertising that touts high PUFA oils as being heart healthy. While this message might have some validity for someone eating a very low fat diet, at the high fat end of the dietary fat spectrum, it is completely invalid (if not dangerous).”

Japanese, Chinese, ALDH2*2 mutation (Chen et al., 2008; Jiang et al., 2017; Ohta et al., 2004; Takagi et al., 2002)

Seed oils and NAFLD (Van Name et al., 2020)

Note: apparently I didn’t make it clear: what got approved by the FDA was Omegaven, which was the alternative, non-toxic treatment to Intralipid. The references cited below make that clear, I did not.

Introducion of Intralipid (NAFLD model) in 1961 (Gura, 2020)

Omegaven and liver failure (Anez-Bustillos et al., 2016)

“Every single infusion that includes omega-6 fats causes liver disease…” (Gura, 2017)

“…prevents Omegaven from healing liver failure…” (Gura, 2020)

Soybean oil (Intralipid) induces insulin resistance (Chow et al., 2014; Felber & Vannotti, 1964)

RCT on Intralipid (Gura, 2020)

Farmed salmon (Midtbø et al., 2013)

Tukisenta eating sweet potatoes (Sinnett & Whyte, 1973)

Coconut oil not obesogenic (Benz, 2015; Deol et al., 2015, 2017; “GMO-Sourced Soybean Oil Causes Less Obesity than Conventional Oil,” 2017; Pittalwala, 2017)

Kitavans and coconut oil (Lindeberg et al., 1994)

Talked to people in India (dLife Healthcare Foundation, 2021)

Sunlight and sunburn (Black et al., 1992; Black & Rhodes, 2001)

TP53 mutation (Baugh et al., 2018; Cenini et al., 2008; Feng et al., 2004; Gao et al., 2019; Moulder et al., 2018; Perri et al., 2016; van der Pols et al., 2011)

Andes indigenous population (Wayuu) (Lennon et al., 2019)

 

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